Results 131 to 140 of about 498,663 (149)

Selective nuclear export mechanism of small RNAs

Current Opinion in Structural Biology, 2011
The timely nuclear-cytoplasmic translocation of proteins and RNAs by importins and exportins is important for controlling biological processes. Since the 2004 publication of the first exportin structure, Cse1p, the X-ray structures of exportin-5 complexed with pre-microRNA, exportin-t complexed with tRNA, and three CRM1-related structures have revealed
Eiki Yamashita, Chimari Jiko, Soo Jae Lee, Tomitake Tsukihara, Tomitake Tsukihara   +4 more
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Synthesis of Small Nuclear RNAs

1991
There are seven abundant and several less abundant capped small nuclear RNAs characterized in mammalian cells. These RNAs are all capped on their 5′ ends and were designated U snRNAs because the U1-U3 snRNAs initially studied were rich in uridylic acid (Hodnett and Busch 1968).
R. Singh, R. Reddy
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Pseudourine formation in small nuclear RNAs

Biochimie, 1994
Recent in vitro studies on the formation of pseudouridine (psi) in the spliceosomal small nuclear RNAs (snRNA) are reviewed. Multiple psi synthase activities, in some cases more that one per snRNA, are responsible for this modification of uridine. There is a requirement for Sm protein binding for the efficient formation of psi in U5 RNA but not for the
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Small molecular weight monodisperse nuclear RNA

Journal of Molecular Biology, 1968
Abstract The nuceloplasm and nucleolus of HeLa cells contain six distinct low molecular weight species of RNA. Their size, as estimated from electrophoretic mobility, ranges from 100 to 180 nucleotides. These RNA species are long-lived and do not appear to be precursor to any cytoplasmic product.
Sheldon Penman, Robert A. Weinberg
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Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

Nature Reviews Molecular Cell Biology, 2007
Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc)RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function.
A. Gregory Matera, Rebecca M. Terns, Michael P. Terns   +2 more
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Small nuclear RNAs and pre-mRNA splicing

Current Opinion in Cell Biology, 1994
Genetic and biochemical studies have recently shown that the splice sites in nuclear pre-mRNAs are aligned for the transesterification reactions through a collaboration between U5 and U6 small nuclear RNAs, which form the heart of a network of RNA-based interactions in the active spliceosome.
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[35] Compilation of small nuclear RNA sequences

1989
Publisher Summary This chapter presents compilation of small nuclear RNA sequences. It illustrates the compilation of small nuclear RNA (snRNA) sequences for U1–U8 RNA and yeast. The abbreviations used for base and sugar modifications are m 3 G, N 2,2,7 -trimethylguanosine; A3, 2 ' - O -methyladenosine; C3, 2 ' - O -methylcytosine; G3, 2 ' - O ...
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Formation of Pseudouridine in U5 Small Nuclear RNA

Biochemistry, 1994
The formation of pseudouridine (psi) on U5 small nuclear RNA (U5 snRNA) was studied using an in vitro modification system. Labeled U5 RNA, synthesized in vitro and therefore unmodified, was incubated in reactions containing S100 and/or nuclear extracts (NE) from HeLa cells, and the levels of psi were determined.
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Small Nuclear RNAs: RNA Sequences, Structure, and Modifications

1988
All eukaryotic cells contain multiple small nuclear RNAs, designated U-sn At present ten U-snRNAs have been identified; they account for about 1% total mammalian cellular RNA. Of these, the U1 to U8 snRNAs have been sively characterized. All the U-snRNAs contain a 5′-cap structure consis a blocked 5′-terminal pyrophosphate linkage; except for U6 RNA, a
Ram Reddy, Harris Busch
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Posttranscriptional Modifications in the U Small Nuclear RNAs [PDF]

, 2014
This chapter deals with the posttranscriptional modifications of metabolically stable small nuclear RNAs (snRNAs) and the possible link to the function of these molecules. A study of the posttranscriptional modifications in the AT-AC specific spliceosomal snRNAs was started, and the results obtained are described in this chapter.
Séverine Massenet, Annie Mougin, Christiane Branlant   +2 more
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