Results 21 to 30 of about 152,090 (265)

Biased Hypermutagenesis Associated with Mutations in an Untranslated Hairpin of an RNA Virus [PDF]

Journal of Virology, 2004
ABSTRACT The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations.
John C, McCormack, Anne E, Simon
openaire   +2 more sources

circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p

Frontiers in Cardiovascular Medicine, 2021
Circular RNA (circRNA) is a subclass of non-coding RNAs that enables the circular transcripts resistant to the exonuclease digestion. Iron homeostasis is essential for the body to maintain normal physiological functions.
Haoyuan Zheng, Lin Shi, Changci Tong, Yunen Liu, Yunen Liu, Mingxiao Hou, Mingxiao Hou, Mingxiao Hou   +7 more
doaj   +1 more source

XIAP 3′-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma

Tumor Biology, 2017
X-linked inhibitor of apoptosis protein functions as an intrinsic regulator of apoptosis by inhibition of caspase activity and possesses a pivotal role in human cancer development and progression.
Wen-Yong Wu, Si-Qi Tao, Xiao-Nan Wang, Peter E Lobie, Zheng-Sheng Wu   +4 more
doaj   +1 more source

U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity.

PLoS ONE, 2014
The viral RNA-dependent RNA polymerase has been found to contribute to efficient replication in mammalian systems and to the high pathogenicity of H5N1 influenza A virus in humans and other mammals. The terminal untranslated regions of the viral segments
Wei Sun, Jing Li, Pengfei Han, Yinhui Yang, Xiaoping Kang, Yuchang Li, Jiaming Li, Yu Zhang, Xiaoyan Wu, Tao Jiang, Chengfeng Qin, Yi Hu, Qingyu Zhu   +12 more
doaj   +1 more source

A factor that specifically binds to the 5'‐untranslated region of encephalomyocarditis virus RNA [PDF]

FEBS Letters, 1990
A protein factor that specifically binds to the 5'‐untranslated region of encephalomyocarditis virus (EMCV) RNA has been found in extracts of ascites carcinoma Krebs‐2 cells. This was done using UV‐irradiation on extracts supplemented with in vitro synthesized 32P‐labelled transcripts followed by analysis of crosslinked proteins by SDS‐polyacrylamide ...
Borovjagin, A.V., Evstafieva, A.G., Ugarova, T.Yu., Shatsky, I.N.   +3 more
openaire   +2 more sources

Control of Listeria monocytogenes virulence by 5′-untranslated RNA

Trends in Microbiology, 2006
The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to post-transcriptional regulation as a result of their long 5'-untranslated region (5'-UTR).
Loh, E, Gripenland, J, Johansson, J
openaire   +3 more sources

Discovering non-coding RNA elements in Drosophila 3' untranslated regions [PDF]

International Journal of Bioinformatics Research and Applications, 2014
The Non-Coding RNA (ncRNA) elements in the 3' Untranslated Regions (3'-UTRs) are known to participate in the genes' post-transcriptional regulations. Inferring co-expression patterns of the genes through clustering these 3'-UTR ncRNA elements will provide invaluable insights for studying their biological functions. In this paper, we propose an improved
Cuncong Zhong, Justen Andrews, Shaojie Zhang 0001   +2 more
openaire   +4 more sources

Structural Components for Amplification of Positive and Negative Strand VEEV Splitzicons

Frontiers in Molecular Biosciences, 2018
RNA is a promising nucleic acid technology for both vaccines and therapeutics, and replicon RNA has gained traction as a next-generation RNA modality. Replicon RNA self-amplifies using a replicase complex derived from alphaviral non-structural proteins ...
Anna K. Blakney, Paul F. McKay, Robin J. Shattock   +2 more
doaj   +1 more source

Functions of the 5′- and 3′-untranslated regions of tobamovirus RNA

Virus Research, 2015
The tobamovirus genome is a 5'-m(7)G-capped RNA that carries a tRNA-like structure at its 3'-terminus. The genomic RNA serves as the template for both translation and negative-strand RNA synthesis. The 5'- and 3'-untranslated regions (UTRs) of the genomic RNA contain elements that enhance translation, and the 3'-UTR also contains the elements necessary
Tetsuya, Chujo, Kazuhiro, Ishibashi, Shuhei, Miyashita, Masayuki, Ishikawa   +3 more
openaire   +2 more sources

Transcription termination and antitermination of bacterial CRISPR arrays

eLife, 2020
A hallmark of CRISPR-Cas immunity systems is the CRISPR array, a genomic locus consisting of short, repeated sequences (‘repeats’) interspersed with short, variable sequences (‘spacers’). CRISPR arrays are transcribed and processed into individual CRISPR
Anne M Stringer, Gabriele Baniulyte, Erica Lasek-Nesselquist, Kimberley D Seed, Joseph T Wade   +4 more
doaj   +1 more source