Results 21 to 30 of about 907,910 (309)

Protonatable Hairpins Are Conserved in the 5'-Untranslated Region of Tymovirus RNAs [PDF]

Nucleic Acids Research, 1996
The secondary structures of the 5'-untranslated region (5'-UTR) of five different tymoviruses have been determined by structure probing, computer prediction and sequence comparison. Despite large sequence differences, there are remarkable similarities in the secondary structure.
Hellendoorn, K., Michiels, P.J.A., Buitenhuis, R., Pleij, C.W.A.   +3 more
openaire   +4 more sources

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
core   +1 more source

Biased Hypermutagenesis Associated with Mutations in an Untranslated Hairpin of an RNA Virus [PDF]

Journal of Virology, 2004
ABSTRACT The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations.
John C, McCormack, Anne E, Simon
openaire   +2 more sources

p300-Mediated H3K18 Lactylation Drives Radiation-Induced Pulmonary Fibrosis via VIRMA-Dependent m6A Modification of GATA3. [PDF]

Adv Sci (Weinh)
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Yi J, Wang M, Yu D, Zhao M, Wang X, Li S, Han X, Wei W, Jin S.   +8 more
europepmc   +2 more sources

Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei:evidence for genome-wide conservation of life-cycle stage-specific regulatory elements [PDF]

, 2006
Trypanosomes represent an excellent model for the post-transcriptional regulation of gene expression because their genome is organized into polycistronic transcription units.
Katelyn Fenn, Matthew Mayho, Keith Matthews, Fenn, Katelyn, Matthews, Keith; id_orcid, Crosthwaite, Susan, Susan Crosthwaite, Craddy, Paul, Mayho, Matthew, Matthews, Keith, Paul Craddy   +10 more
core   +1 more source

Neuronal Untranslated BC1 RNA: Targeted Gene Elimination in Mice [PDF]

Molecular and Cellular Biology, 2003
Despite the potentially important roles of untranslated RNAs in cellular form or function, genes encoding such RNAs have until now received surprisingly little attention. One such gene encodes BC1 RNA, a small non-mRNA that is delivered to dendritic microdomains in neurons. We have now eliminated the BC1 RNA gene in mice.
Boris V, Skryabin, Valentina, Sukonina, Ursula, Jordan, Lars, Lewejohann, Norbert, Sachser, Ilham, Muslimov, Henri, Tiedge, Jürgen, Brosius   +7 more
openaire   +2 more sources

Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs [PDF]

, 2010
Theis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol
Corinna Theis, Theis, Corinna, Moulton, Vincent, Singh, Mona, Stefan Janssen, Janssen, Stefan ; https://orcid.org/, Robert Giegerich, Giegerich, Robert   +7 more
core   +1 more source

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity.

PLoS ONE, 2014
The viral RNA-dependent RNA polymerase has been found to contribute to efficient replication in mammalian systems and to the high pathogenicity of H5N1 influenza A virus in humans and other mammals. The terminal untranslated regions of the viral segments
Wei Sun, Jing Li, Pengfei Han, Yinhui Yang, Xiaoping Kang, Yuchang Li, Jiaming Li, Yu Zhang, Xiaoyan Wu, Tao Jiang, Chengfeng Qin, Yi Hu, Qingyu Zhu   +12 more
doaj   +1 more source