RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
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Sequences at the 3′ Untranslated Region of Bamboo Mosaic Potexvirus RNA Interact with the Viral RNA-Dependent RNA Polymerase [PDF]
Journal of Virology, 2001 ABSTRACT The 3′ untranslated region (UTR) of bamboo mosaic potexvirus (BaMV) genomic RNA was found to fold into a series of stem-loop structures including a pseudoknot structure. These structures were demonstrated to be important for viral RNA replication and were believed to be recognized by the replicase (C.-P.
C Y, Huang +4 more
openaire +2 more sources
Tunable protein synthesis by transcript isoforms in human cells
eLife, 2016 Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated ...
Stephen N Floor, Jennifer A Doudna
doaj +1 more source
Transcription termination and antitermination of bacterial CRISPR arrays
eLife, 2020 A hallmark of CRISPR-Cas immunity systems is the CRISPR array, a genomic locus consisting of short, repeated sequences (‘repeats’) interspersed with short, variable sequences (‘spacers’). CRISPR arrays are transcribed and processed into individual CRISPR
Anne M Stringer +4 more
doaj +1 more source
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
, 2007 RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
core +1 more source
Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?
PLoS Medicine, 2008 Thomas Hughes and Pamela Jones discuss the implications of a new study on the 5' non-coding region of vascular endothelial growth factor mRNA and its influence on gene expression.
Hughes, T.A., Jones, P.F.
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Secondary structure models of the 3′ untranslated regions of diverse R2 RNAs [PDF]
RNA, 2004 The RNA structure of the 3′ untranslated region (UTR) of the R2 retrotransposable element is recognized by the R2-encoded reverse transcriptase in a reaction called target primed reverse transcription (TPRT). To provide insight into structure–function relationships important for TPRT, we have created alignments that reveal the secondary structure for ...
Amy M, Ruschak +6 more
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Evolutionary conservation of the AU-rich 3'untranslated region of messenger RNA. [PDF]
Proceedings of the National Academy of Sciences, 1994 AU-rich sequence motifs (specifically sequences containing reiterations of AUUUA) are found in the 3' untranslated region of mammalian mRNAs encoding cytokines, adhesion molecules, and protooncogenes. Because these AU-rich elements (3'AURE) have been observed to reduce the stability and translational efficiency of transcripts that contain them, and ...
M A, Asson-Batres +4 more
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Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]
, 2014 The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct and complete annotation in addition to the underlying genomic sequence is particularly important when interpreting the results ...
Junfang Song +29 more
core +1 more source
Developmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
Cell Reports, 2023 Summary: The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether similar processes exist in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors
Therese Solberg +3 more
doaj +1 more source