Results 31 to 40 of about 152,090 (265)

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations

Nature Communications, 2020
G-quadruplexes (G4s) are secondary structures that can form in both DNA and RNA from guanine-rich sequences which are enriched in untranslated regions (UTRs). Here, Lee et al.
David S. M. Lee, Louis R. Ghanem, Yoseph Barash   +2 more
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Sequences at the 3′ Untranslated Region of Bamboo Mosaic Potexvirus RNA Interact with the Viral RNA-Dependent RNA Polymerase [PDF]

Journal of Virology, 2001
ABSTRACT The 3′ untranslated region (UTR) of bamboo mosaic potexvirus (BaMV) genomic RNA was found to fold into a series of stem-loop structures including a pseudoknot structure. These structures were demonstrated to be important for viral RNA replication and were believed to be recognized by the replicase (C.-P.
C Y, Huang, Y L, Huang, M, Meng, Y H, Hsu, C H, Tsai   +4 more
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Tunable protein synthesis by transcript isoforms in human cells

eLife, 2016
Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated ...
Stephen N Floor, Jennifer A Doudna
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Secondary structure models of the 3′ untranslated regions of diverse R2 RNAs [PDF]

RNA, 2004
The RNA structure of the 3′ untranslated region (UTR) of the R2 retrotransposable element is recognized by the R2-encoded reverse transcriptase in a reaction called target primed reverse transcription (TPRT). To provide insight into structure–function relationships important for TPRT, we have created alignments that reveal the secondary structure for ...
Amy M, Ruschak, David H, Mathews, Arkadiusz, Bibillo, Sherry L, Spinelli, Jessica L, Childs, Thomas H, Eickbush, Douglas H, Turner   +6 more
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Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?

PLoS Medicine, 2008
Thomas Hughes and Pamela Jones discuss the implications of a new study on the 5' non-coding region of vascular endothelial growth factor mRNA and its influence on gene expression.
Hughes, T.A., Jones, P.F.
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RNA-protein interactions within the 3 ' untranslated region of vimentin mRNA [PDF]

Nucleic Acids Research, 1997
Several functions have been attributed to protein binding within the 3'untranslated region (3'UTR) of mRNA, including mRNA localization, stability, and translational repression. Vimentin is an intermediate filament protein whose 3'untranslated sequence is highly conserved between species.
Z E, Zehner, R K, Shepherd, J, Gabryszuk, T F, Fu, M, Al-Ali, W M, Holmes   +5 more
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Evolutionary conservation of the AU-rich 3'untranslated region of messenger RNA. [PDF]

Proceedings of the National Academy of Sciences, 1994
AU-rich sequence motifs (specifically sequences containing reiterations of AUUUA) are found in the 3' untranslated region of mammalian mRNAs encoding cytokines, adhesion molecules, and protooncogenes. Because these AU-rich elements (3'AURE) have been observed to reduce the stability and translational efficiency of transcripts that contain them, and ...
M A, Asson-Batres, S L, Spurgeon, J, Diaz, T G, DeLoughery, G C, Bagby   +4 more
openaire   +2 more sources

Developmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium

Cell Reports, 2023
Summary: The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether similar processes exist in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors
Therese Solberg, Victor Mason, Chundi Wang, Mariusz Nowacki   +3 more
doaj   +1 more source

EZH2: A Crucial Competing Endogenous RNA in Cancer Research-A Scoping Review

Advanced Biomedical Research
Recently, research on the competing endogenous RNAs (ceRNAs) in cancer has been in full swing, emphasizing their importance as critical RNAs in cancer progression.
Sadra Salehi-Mazandarani, Sharareh Mahmoudian-Hamedani, Ziba Farajzadegan, Parvaneh Nikpour   +3 more
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miR-19a-3p as a Candidate oncomiRNA in Cervical Cancer: Insights From a Bioinformatic Analysis

Frontiers in Bioscience-Landmark
Background: Cervical cancer (CC) remains a significant threat to global public health, with high incidence and mortality rates. Understanding the molecular mechanisms governing CC progression is critical for developing novel diagnostic
Ramón Antaño-Arias, Francisco Israel Torres-Rojas, Gabriela Elizabeth Campos-Viguri, Adán Arizmendi-Izazaga, Julio Ortiz-Ortiz, Roberto Dircio-Maldonado, Judit Alarcón-Millán, Fredy David Bartolo-Ángel, Alejandro Fiallo-Rodríguez, Hilda Jiménez-Wences, Eric Genaro Salmerón-Bárcenas   +10 more
doaj   +1 more source