Results 121 to 130 of about 2,788,248 (339)

Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]

, 2004
For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core   +3 more sources

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

Science, 2019
RNA modification meets immune metabolism N6-methyladenosine (m6A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m6A demethylase activity after viral infection, leading to increased m6A and reduced ...
Yang Liu, Yuling You, Zhike Lu, Jiang Yang, Panpan Li, Lun Liu, Henan Xu, Ya-Zhou Niu, Xuetao Cao   +8 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1

Cell Reports, 2019
Summary: Long noncoding RNAs (lncRNAs) participate in host antiviral defense by modulating immune responses. However, it remains largely unexplored how viruses exploit interferon (IFN)-independent host lncRNAs to facilitate viral replication.
Jing Wang, Yongxin Zhang, Quanjie Li, Jianyuan Zhao, Dongrong Yi, Jiwei Ding, Fei Zhao, Siqi Hu, Jinming Zhou, Tao Deng, Xiaoyu Li, Fei Guo, Chen Liang, Shan Cen   +13 more
doaj   +1 more source

Regulation of Viral Infection by the RNA Modification N6-methyladenosine.

Annual Review of Virology, 2019
In recent years, the RNA modification N6-methyladenosine (m6A) has been found to play a role in the life cycles of numerous viruses and also in the cellular response to viral infection.
Graham D. Williams, Nandan S. Gokhale, Stacy M. Horner   +2 more
semanticscholar   +1 more source

Ribosomal frameshifting on viral RNAs

Journal of General Virology, 1995
Introduction. Accurate maintenance of the translational reading frame by ribosomes is essential for the production of functional proteins and unsurprisingly, errors in frame maintenance have been estimated to occur at rates probably lower than 5 × 10-5 per codon (Kurland, 1992).
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Mycoviruses, RNA Silencing, and Viral RNA Recombination [PDF]

, 2011
In contrast to viruses of plants and animals, viruses of fungi, mycoviruses, uniformly lack an extracellular phase to their replication cycle. The persistent, intracellular nature of the mycovirus life cycle presents technical challenges to experimental design. However, these properties, coupled with the relative simplicity and evolutionary position of
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells

PLoS Pathogens, 2018
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes ...
Wenshuo Zhou, M. Woodson, B. Neupane, F. Bai, M. Sherman, K. Choi, Girish Neelakanta, Hameeda Sultana   +7 more
semanticscholar   +1 more source