Results 101 to 110 of about 8,817,235 (253)

Protein-RNA interactions during stress responses in Saccharomyces cerevisiae [PDF]

The survival and adaptability of living organisms depend on their ability to adjust to environmental changes. In the yeast Saccharomyces cerevisiae, glucose serves as the preferential carbon and energy source.
Ristová, Michaela
core   +1 more source

Proximity labeling to detect RNA–protein interactions in live cells

FEBS Open Bio, 2019
RNA biology is orchestrated by the dynamic interactions of RNAs and RNA‐binding proteins (RBPs). In the present study, we describe a new method of proximity‐dependent protein labeling to detect RNA–protein interactions [RNA‐bound protein proximity ...
Mingxing Lu, Wencheng Wei
doaj   +1 more source

Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

eLife, 2017
Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the combinatorial problem of a non-random selection of a full genomic set of distinct RNAs. This process
Alexander Borodavka, Eric C Dykeman, Waldemar Schrimpf, Don C Lamb   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

RNA-RNA and RNA-protein interactions in coronavirus replication and transcription

, 2020
Coronavirus (CoV) RNA synthesis includes the replication of the viral genome, and the transcription of sgRNAs by a discontinuous mechanism. Both processes are regulated by RNA sequences such as the 5¿ and 3¿ untranslated regions (UTRs), and the ...
Solá Gurpegui, Isabel, Enjuanes Sánchez, Luis, Zúñiga Lucas, Sonia, Mateos-Gomez, Pedro A., Almazán, Fernando   +4 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

RNApedia: a database of structural protein–RNA interactions

Frontiers in Bioinformatics
The interaction between RNAs and RNA-binding proteins (RBPs) is fundamental for gene expression and regulation of cellular homeostasis. The growing interest in understanding protein-RNA complexes and their use in developing biotechnological solutions has
Luana Luiza Bastos, Diego Mariano, Pedro M. Martins, Rafael Pereira Lemos, Rafael Eduardo Oliveira Rocha, Leandro Morais de Oliveira, Sheila Cruz Araújo, Tatiane Senna Bialves, Raquel C. de Melo-Minardi   +8 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source