Results 81 to 90 of about 1,027,244 (259)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Protein-RNA interactions: a structural analysis

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP

, 2009
Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ...
Nina Morgner, Hernández Helena, Makarov Evgeny M., H. Hernández (7607219), Yutaka Muto, D. P. Krummel (7607234), Helena Hernández, Carol V Robinson, O. V. Makarova (7607222), Robinson, CV, Krummel, DP, Daniel Pomeranz Krummel, Hernandez, H, Evgeny M Makarov, Makarova, OV, Y. Muto (7607231), Olga V Makarova, Robinson Carol V., E. M. Makarov (7607225), N. Morgner (7607228), Makarov, EM, Robinson, Carol, Makarova Olga V., Muto Yutaka, Krummel Daniel Pomeranz, C. V. Robinson (7607237), Morgner, N, Morgner Nina, Muto, Y   +28 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Analysis of High-Throughput Data - Protein-Protein Interactions, Protein Complexes and RNA Half-life

, 2009
The development of high-throughput techniques has lead to a paradigm change in biology from the small-scale analysis of individual genes and proteins to a genome-scale analysis of biological systems.
Friedel, Caroline Christina
core  

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication

, 2011
DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Di Cicco, Giulia, Maga, Giovanni, Giulia Di Cicco, Anna Garbelli, Beermann, Sandra, Dietrich, Ursula, Giovanni Maga, Ursula Dietrich, Sandra Beermann, Garbelli, Anna   +9 more
core   +1 more source

RNA interactions

, 2022
S.20-38Noncoding RNAs form an indispensible component of the cellular information processing networks, a role that crucially depends on the specificity of their interactions among each other as well as with DNA and protein. Patterns of intramolecular and
Stadler, Peter F., Marz, Manja
core   +1 more source