Results 61 to 70 of about 1,027,244 (259)

A comparative analysis of machine learning classifiers for predicting protein-binding nucleotides in RNA sequences

Computational and Structural Biotechnology Journal, 2022
RNA-protein interactions play vital roles in driving the cellular machineries. Despite significant involvement in several biological processes, the underlying molecular mechanism of RNA-protein interactions is still elusive.
Ankita Agarwal, Kunal Singh, Shri Kant, Ranjit Prasad Bahadur   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Interconnections between m 6 A RNA modification, RNA structure, and protein–RNA complex assembly

Life Science Alliance
This review summarizes current knowledge and future directions on the mechanisms that govern the interplay between m 6 A RNA modification, RNA folding, and protein–RNA interactions, focusing on the mechanisms and available quantitative information ...
Simone Höfler, Olivier Duss
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T, Webb, Shaun, Barrass, J David, Beggs, Jean D   +3 more
core   +1 more source

Decoding the role of the RNA binding activity of p53

, 2022
p53 is a key tumour suppressor, mutated in over half of cancers. p53’s ability to form extensive protein interactions, along with its function as a sequence-specific transcription factor, are well documented due to their roles in canonical p53 tumour ...
Moore, Samantha Louise
core   +1 more source

RPI-Bind: a structure-based method for accurate identification of RNA-protein binding sites

Scientific Reports, 2017
RNA and protein interactions play crucial roles in multiple biological processes, while these interactions are significantly influenced by the structures and sequences of protein and RNA molecules.
Jiesi Luo, Liang Liu, Suresh Venkateswaran, Qianqian Song, Xiaobo Zhou   +4 more
doaj   +1 more source

A Brief Review of RNA-Protein Interaction Database Resources

Non-Coding RNA, 2017
RNA-protein interactions play critical roles in various biological processes. By collecting and analyzing the RNA-protein interactions and binding sites from experiments and predictions, RNA-protein interaction databases have become an essential resource
Ying Yi, Yue Zhao, Yan Huang, Dong Wang
doaj   +1 more source