Results 61 to 70 of about 7,392,133 (313)

Regulation of Pluripotency by RNA Binding Proteins [PDF]

Cell Stem Cell, 2014
Establishment, maintenance, and exit from pluripotency require precise coordination of a cell's molecular machinery. Substantial headway has been made in deciphering many aspects of this elaborate system, particularly with respect to epigenetics, transcription, and noncoding RNAs. Less attention has been paid to posttranscriptional regulatory processes
Ye, Julia, Blelloch, Robert
openaire   +4 more sources

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]

, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Wöhnert, Jens, Nasiri, Hamid Reza, Fürtig, Boris, Buck, Janina, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +5 more
core   +1 more source

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

Nature Communications, 2023
The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis and cell proliferation and have been implicated in cancer. RBM5 harbors structural modules for
Komal Soni, Pravin Kumar Ankush Jagtap, Santiago Martínez-Lumbreras, Sophie Bonnal, Arie Geerlof, Ralf Stehle, Bernd Simon, Juan Valcárcel, Michael Sattler   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

RNA-binding proteins in neurological diseases [PDF]

Science China Life Sciences, 2014
Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs ...
Zhou, HuaLin, Mangelsdorf, Marie, Liu, JiangHong, Zhu, Liu, Wu, Jane Y.   +4 more
openaire   +5 more sources

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]

, 2009
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Kanako Kuwasako, Naohiro Kobayashi, Shirouzu, Mikako, Mari Takahashi, Yutaka Muto, Takahashi, Mari, Someya, Tatsuhiko, Takanori Kigawa, Kengo Tsuda, Kuwasako, Kanako, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Sugano, Sumio, Akiko Tanaka, Tatsuhiko Someya, Makoto Inoue, Sumio Sugano, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Yokoyama, Shigeyuki, Tsuda, Kengo, Takaho Terada, Shigeyuki Yokoyama, Tanaka, Akiko, Güntert, Peter   +27 more
core   +2 more sources

Dissection and prediction of RNA-binding sites on proteins

Biomolecular Concepts, 2010
RNA-binding proteins are involved in many important regulatory processes in cells and their study is essential for a complete understanding of living organisms. They show a large variability from both structural and functional points of view.
Pérez-Cano Laura, Fernández-Recio Juan
doaj   +1 more source

SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells. [PDF]

PLoS ONE, 2016
The RNA-binding protein La is involved in several aspects of RNA metabolism including the translational regulation of mRNAs and processing of pre-tRNAs.
Venkatesh Kota, Gunhild Sommer, Chantal Durette, Pierre Thibault, Erna A van Niekerk, Jeffery L Twiss, Tilman Heise   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

RNA-Binding Proteins in Plant Immunity [PDF]

Journal of Pathogens, 2011
Plant defence responses against pathogen infection are crucial to plant survival. The high degree of regulation of plant immunity occurs both transcriptionally and posttranscriptionally. Once transcribed, target gene RNA must be processed prior to translation. This includes polyadenylation,5′capping, editing, splicing, and mRNA export.
Woloshen, Virginia, Huang, Shuai, Li, Xin   +2 more
openaire   +2 more sources