Results 41 to 50 of about 1,875,767 (314)

Characterization of post-transcriptional regulatory network of RNA-binding proteins using computational predictions and deep sequencing data [PDF]

, 2013
This report is divided into three parts: Data Analysis, Mathematical Modeling and Conclusion and future directions. In the Data Analysis part, various methods and tools for characterizing the post-transcriptional regulatory networks of RNA-binding ...
Mohsen, Khorshid
core   +1 more source

Beyond RNA-binding domains: determinants of protein–RNA binding

RNA
RNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal, Carmi, Miri, Brodsky, Sagie, Rosenwaser, Zohar, Barkai, Naama, Jonas, Felix   +5 more
openaire   +2 more sources

Alternative polyadenylation and RNA-binding proteins [PDF]

Journal of Molecular Endocrinology, 2016
Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire   +3 more sources

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin   +3 more
core   +1 more source

RNA Binding Proteins in the miRNA Pathway [PDF]

International Journal of Molecular Sciences, 2015
microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated.
Connerty, Patrick, Ahadi, Alireza, Hutvagner, Gyorgy   +2 more
openaire   +2 more sources

RNA-Binding Proteins in Acute Leukemias [PDF]

International Journal of Molecular Sciences, 2020
Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate ...
Konstantin Schuschel, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan-Henning Klusmann, Jessica I Hoell   +5 more
openaire   +2 more sources

Protocol to measure protein-RNA binding using double filter-binding assays followed by phosphorimaging or high-throughput sequencing

STAR Protocols, 2023
Summary: Binding affinity quantitatively describes the strength of a molecular interaction and is reported by the equilibrium dissociation constant (KD).
Joel Vega-Badillo, Phillip D. Zamore, Karina Jouravleva   +2 more
doaj   +1 more source

Transition of plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein pumilio [PDF]

, 2011
Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs.
Gunnar R Mair, Waters, Andrew, Waters, A.P., Prudêncio, M., Joanna Braks, Braks, Joanna, Mair Gunnar R., Braks, J., Theresa Feltwell, Prudêncio, Miguel, Mair, Gunnar R., Gomes-Santos, Carina S. S., Feltwell Theresa, Pain, A., Janse, C., Mota, Maria M., Mota, M.M., Céline Carret, Carret, Céline, Shahid Khan, Gomes, Ana Rita, Khan, S., Miguel Prudêncio, Ana Rita Gomes, Carina S S Gomes-Santos, Mota Maria M., Khan Shahid, Carina S. S. Gomes-Santos, Prudêncio Miguel, Maria M. Mota, Waters Andrew, Gomes-Santos Carina S. S., Gomes-Santos, C.S.S., Gomes, A.R., Mair, G.R., Andrew Waters, Gunnar R. Mair, Gomes Ana Rita, Feltwell, T., Carret Céline, Pain, Arnab, Khan, Shahid, Janse, Chris, Chris Janse, Maria M Mota, Carret, C., Janse Chris, Waters, A., Arnab Pain, Pain Arnab, Feltwell, Theresa, Braks Joanna   +51 more
core   +1 more source

RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides

Pharmaceuticals, 2011
Many genetic and infectious diseases can be targeted at the RNA level as RNA is more accessible than DNA. We seek to develop new approaches for detection and tracking RNA in live cells, which is necessary for RNA-based diagnostics and therapy.
Charles R. Cantor, Natalia E. Broude, Paul Toran, Hung-Wei Yiu, Vadim V. Demidov   +4 more
doaj   +1 more source

Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules

Biomolecules, 2020
Spatiotemporal translational regulation plays a key role in determining cell fate and function. Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and long-term memory formation.
Rie Ohashi, Nobuyuki Shiina
doaj   +1 more source