Results 21 to 30 of about 1,875,767 (314)

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Andrzej Dziembowski, Rafal Tomecki, Tomecki, Rafał, Dziembowski, Andrzej   +3 more
core   +1 more source

RNA-binding protein signaling in adult neurogenesis

Frontiers in Cell and Developmental Biology, 2022
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons.
Jackie Ngai-Man Chan, Dalinda Isabel Sánchez-Vidaña, Dalinda Isabel Sánchez-Vidaña, Shailendra Anoopkumar-Dukie, Yue Li, Lau Benson Wui-Man, Lau Benson Wui-Man   +6 more
doaj   +1 more source

Helical defects in microRNA influence protein binding by TAR RNA binding protein.

PLoS ONE, 2015
BackgroundMicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence.
Roderico Acevedo, Nichole Orench-Rivera, Kaycee A Quarles, Scott A Showalter   +3 more
doaj   +1 more source

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Microbiology Spectrum, 2022
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny   +5 more
doaj   +1 more source

Characterization of Aptamer-Protein Complexes by X-ray Crystallography and Alternative Approaches [PDF]

, 2012
Aptamers are oligonucleotide ligands, either RNA or ssDNA, selected for high-affinity binding to molecular targets, such as small organic molecules, proteins or whole microorganisms.
Levisson, M., Smidt, H., Ruigrok, V.J.B., Mark Levisson, Dijkstra, B.W., Hekelaar, J., Dijkstra, Bauke W., Hauke Smidt, Ruigrok, Vincent J.B.,, van der Oost, John, Bauke W. Dijkstra, Smidt, Hauke,, Hekelaar, Johan, Dijkstra, Bauke W.,, Hekelaar, Johan,, Vincent J. B. Ruigrok, Levisson, Mark,, Oost, J., van der, Levisson, Mark, Smidt, Hauke, Johan Hekelaar, John Van der Oost, van der Oost, J., Oost, John van der,, Ruigrok, Vincent J. B.   +24 more
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Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source

The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance

Technology in Cancer Research & Treatment, 2020
RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS, Fanghui Ding MD, Dan Jiao MS, Qiaozhi Li MS, Hong Ma MS   +4 more
doaj   +1 more source

Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins

Applied Sciences, 2020
RNAs play important roles in gene expression through translation and RNA splicing. Regulation of specific RNAs is useful to understand and manipulate specific transcripts.
Misaki Sugimoto, Akiyo Suda, Shiroh Futaki, Miki Imanishi   +3 more
doaj   +1 more source

Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein

Nature Communications, 2023
Viral RNA-host protein interactions are indispensable during RNA virus transcription and replication, but their detailed structural and dynamical features remain largely elusive. Here, we characterize the binding interface for the SARS-CoV-2 stem-loop 3 (
Dong Zhang, Lulu Qiao, Xiaobo Lei, Xiaojing Dong, Yunguang Tong, Jianwei Wang, Zhiye Wang, Ruhong Zhou   +7 more
doaj   +1 more source

The cold-inducible RNA-binding motif protein 3 (RBM3) prevents cell death through various mechanisms [PDF]

, 2016
Moderate hypothermia promotes the survival of neural cells in a wide range of brain disorders. During hypothermia, a subgroup of proteins including two homologues, RNA-binding motif protein 3 (RBM3) and cold-inducible RNA-binding protein (CIRP), is ...
Zhu, Xinzhou
core   +1 more source