Results 21 to 30 of about 1,319,348 (265)

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Microbiology Spectrum, 2022
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny   +5 more
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Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins

Applied Sciences, 2020
RNAs play important roles in gene expression through translation and RNA splicing. Regulation of specific RNAs is useful to understand and manipulate specific transcripts.
Misaki Sugimoto, Akiyo Suda, Shiroh Futaki, Miki Imanishi   +3 more
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Characterizing the tumor RBP-ncRNA circuits by integrating transcriptomics, interactomics and clinical data

Computational and Structural Biotechnology Journal, 2021
The interactions among non-coding RNA (ncRNA) and RNA binding protein (RBP) are increasingly recognized as one of basic mechanisms in gene regulation, and play a crucial role in cancer progressions.
Leiming Jiang, Qiuyang Chen, Mingrong Bei, Mengting Shao, Jianzhen Xu   +4 more
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Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein

Nature Communications, 2023
Viral RNA-host protein interactions are indispensable during RNA virus transcription and replication, but their detailed structural and dynamical features remain largely elusive. Here, we characterize the binding interface for the SARS-CoV-2 stem-loop 3 (
Dong Zhang, Lulu Qiao, Xiaobo Lei, Xiaojing Dong, Yunguang Tong, Jianwei Wang, Zhiye Wang, Ruhong Zhou   +7 more
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Targeting RNA binding protein in prostate cancer

Molecular & Cellular Oncology, 2017
RNA binding protein (RBP) controls multiple aspects of RNA metabolism and plays crucial roles in many physiopathological contexts, including cancer. We recently identified an RBP HNRNPL as a novel prostate cancer dependency via regulation of RNA splicing,
Teng Fei
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Chloroplast RNA-binding proteins [PDF]

Current Genetics, 2003
Chloroplast gene expression is regulated by nucleus-encoded factors, which mainly act at the post-transcriptional level. Plastid RNA-binding proteins (RBPs) represent good candidates for mediating these functions. The picture emerging from recent analyses is that of a great number of differentially regulated RBPs, which are organized in distinct ...
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Research Progress in RNA-Binding Proteins

International Journal of Molecular Sciences, 2022
RNA-binding proteins are everywhere and accompany RNA molecules at every stage of their molecular life, from “birth” (transcription) through “growing up” (maturation), “active life” (molecular function) until “death” (turnover) [...]
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RNA-Binding Proteins in Acute Leukemias [PDF]

International Journal of Molecular Sciences, 2020
Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate ...
Konstantin Schuschel, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan-Henning Klusmann, Jessica I Hoell   +5 more
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CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders

Non-Coding RNA, 2023
Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated
Yuka Ikeda, Sae Morikawa, Moeka Nakashima, Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Naoko Suga, Ai Tsuji, Satoru Matsuda   +8 more
doaj   +1 more source

Beyond RNA-binding domains: determinants of protein–RNA binding

RNA
RNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal, Carmi, Miri, Brodsky, Sagie, Rosenwaser, Zohar, Barkai, Naama, Jonas, Felix   +5 more
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