Results 71 to 80 of about 7,392,133 (313)

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]

, 2011
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub, Cramer, P., Andreas Mayer, Kramer, Katharina, Niessing, Dierk, Jansen, R., Urlaub, Henning, Heym Roland Gerhard, Heym, R. G., Schmid, M., Mueller, M., Heym, R.G., Müller, Marisa, Schmid Maria, Jansen Ralf-Peter, Cramer Patrick, Niessing, D., Roland Gerhard Heym, Kramer, K., Meyer, A., Urlaub Henning, Mayer, A., Müller Marisa, Jansen, Ralf-Peter, Jansen, R.P., Mayer Andreas, Maria Schmid, Cramer, Patrick, Schmid, Maria, Patrick Cramer, Urlaub, H., Katharina Kramer, Jansen, R.-P., Niessing Dierk, Ralf-Peter Jansen, Kramer Katharina, Müller, M., Heym, R., Mayer, Andreas, Dierk Niessing, Heym, Roland Gerhard, Marisa Müller   +41 more
core   +2 more sources

Predicting RNA-binding residues from evolutionary information and sequence conservation

BMC Genomics, 2010
Background RNA-binding proteins (RBPs) play crucial roles in post-transcriptional control of RNA. RBPs are designed to efficiently recognize specific RNA sequences after it is derived from the DNA sequence. To satisfy diverse functional requirements, RNA
Huang Chun-Chin, Chiu Li-Yuan, Huang Yu-Feng, Huang Chien-Kang   +3 more
doaj   +1 more source

Identification of Intrinsic RNA Binding Specificity of Purified Proteins by in vitro RNA Immunoprecipitation (vitRIP)

Bio-Protocol, 2021
RNA-protein interactions are often mediated by dedicated canonical RNA binding domains. However, interactions through non-canonical domains with unknown specificity are increasingly observed, raising the question how RNA targets are recognized. Knowledge
Marisa Müller , Tamas Schauer, Peter Becker   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Development of methods for the analysis of deep sequencing data; applications to the discovery of functions of RNA-binding proteins [PDF]

, 2014
With the recent advances in nucleotide sequencing technologies, it became easy to generate tens of millions of reads with genome- or transcriptome-wide distribution with reduced cost and high accuracy.
Bilen, Biter
core   +1 more source

The compendium of Arabidopsis thaliana GLYCINE-RICH RNA-BINDING PROTEIN 8 in vivo targets determined by iCLIP

Scientific Data
RNA-binding proteins impact RNA processing including splicing, translation and RNA decay to dictate the fate of RNAs. Thus, insights into RNA-protein interactions in the cell provide insights into regulatory networks regulating gene expression at the ...
Katja Meyer, Martin Lewinski, Tino Köster, Dorothee Staiger   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA-binding protein nucleolin in disease [PDF]

RNA Biology, 2012
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRNA stability and translation, and microRNA processing ...
Kotb, Abdelmohsen, Myriam, Gorospe
openaire   +2 more sources

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source

Contribution of disordered regions of the essential protein GEMIN5 to RNA binding

Life Science Alliance
The RNA-binding domain of the human GEMIN5 protein consists of an oligomerizing extended surface, including a serine-rich motif and a disordered acidic cluster that cooperatively regulate RNA binding.
Rosario Francisco-Velilla, Azadeh Nahavandi Araghi, Jorge Ramajo, Salvador Abellan, Encarnacion Martinez-Salas   +4 more
doaj   +1 more source