Results 91 to 100 of about 1,640,882 (289)

Preliminary study on the mechanism of RNA-binding protein as a drug target of clofoctol [PDF]

Jichu yixue yu linchuang, 2020
Objective To explore the molecular mechanism of anti-glioma by clofoctol targeting on RNA-binding proteins. Methods Biotin pull-down experiments were used to detect the binding of RNA-binding protein UNR (upstream of N-ras) to the target gene Krüppel ...
ZHANG Mei-lian, WANG Zhi-xing, HU Yan, RAN Kun-nian, HAN Wei, PENG Xiao-zhong
doaj  

Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]

, 2014
This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

The compendium of Arabidopsis thaliana GLYCINE-RICH RNA-BINDING PROTEIN 8 in vivo targets determined by iCLIP

Scientific Data
RNA-binding proteins impact RNA processing including splicing, translation and RNA decay to dictate the fate of RNAs. Thus, insights into RNA-protein interactions in the cell provide insights into regulatory networks regulating gene expression at the ...
Katja Meyer, Martin Lewinski, Tino Köster, Dorothee Staiger   +3 more
doaj   +1 more source

Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]

, 2013
The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun, Doudna, Jennifer A, Zhou, Kaihong   +2 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

Cell Reports, 2012
Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here, we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA ...
Stephanie C. Huelga, Anthony Q. Vu, Justin D. Arnold, Tiffany Y. Liang, Patrick P. Liu, Bernice Y. Yan, John Paul Donohue, Lily Shiue, Shawn Hoon, Sydney Brenner, Manuel Ares, Jr., Gene W. Yeo   +11 more
doaj   +1 more source

Protein interactions in Xenopus germ plasm RNP particles [PDF]

, 2013
Hermes is an RNA-binding protein that we have previously reported to be found in the ribonucleoprotein (RNP) particles of Xenopus germ plasm, where it is associated with various RNAs, including that encoding the germ line determinant Nanos1.
A Anyanful, A Mir, AM Hulstrand, AT Hertig, Barbara Bardoni, C Hudson, C Yost, CA Schneider, CD Hu, D Jin, DL Gard, F Bontems, F Lai, FF Lai, FL Marlow, GT Morgan, Hugh R. Woodland, HW Song, HY Li, I Yanai, J Heasman, JB Bowes, JK Joung, JK Yisraeli, K Kosaka, KL Poon, LA Berekelya, M Claussen, M Kloc, M Kloc, ML King, NP Torpey, P Anderson, RJ Machado, RS Hames, S Miyamoto, S Nijjar, Sarbjit Nijjar, SM Bilinski, T Fukuda, TK Kerppola, WV Gerber, WV Gerber, Y Saka, Y Zhou, ZF Nizami   +45 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]

, 2008
Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D., Luo, Liqun, Penton, Andrea, Watts, Ryan J.   +3 more
core   +1 more source