Results 31 to 40 of about 465,221 (120)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad, Saima Ikram, Fawad Ahmad, Irshad Ur Rehman, Maryam Mushtaq   +4 more
doaj  

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

Viruses, 2010
More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill, Matthias Götte, Jean A. Bernatchez   +2 more
doaj   +1 more source

Functional Importance of the Hydrophobic Residue 362 in Influenza A PB1 Subunit

Viruses, 2023
PB1, acting as the catalytic subunit of the influenza polymerase, has numerous sequentially and structurally conserved regions. It has been observed that the slight modification of residues in PB1 would greatly affect the polymerase activity and even ...
Johnson Jor-Shing Chan, Yun-Sang Tang, Chun-Yeung Lo, Pang-Chui Shaw   +3 more
doaj   +1 more source

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

Virology Journal, 2007
Background Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases.
Vaccaro Joseph A, Freistadt Marion S, Eberle Karen E   +2 more
doaj   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Frontiers in Microbiology, 2022
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai, Kanasap Kaewchim, Kanasap Kaewchim, Techit Thavorasak, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra   +12 more
doaj   +1 more source

Identifying Different Mutation Sites Leading to Resistance to the Direct-Acting Antiviral (DAA) Sofosbuvir in Hepatitis C Virus Patients from Egypt

Microorganisms, 2022
The hepatitis C virus (HCV) is a major global health challenge and a leading cause of morbidity and mortality. Many direct-acting antivirals (DAAs) target essential macromolecules involved in the virus’ life cycle.
Aly Atef Shoun, Rania Abozahra, Kholoud Baraka, Mai Mehrez, Sarah M. Abdelhamid   +4 more
doaj   +1 more source

Electrostatic map of T7 DNA. Comparative analysis of functional and electrostatic properties of T7 RNA polymerase specific promoters [PDF]

, 2013
The entire T7 bacteriophage genome contains 39937 base pairs (Database NCBI RefSeq N1001604). Here, electrostatic potential distribution around double helical T7 DNA was calculated by Coulomb method using the computer program of Sorokin A.A. Electrostatic profiles of 17 promoters recognized by T7 phage specific RNA polymerase were analyzed.
arxiv   +1 more source

A Perspective on the Enhancer Dependent Bacterial RNA Polymerase

Biomolecules, 2015
Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression.
Nan Zhang, Martin Buck
doaj   +1 more source

Model of Transcriptional Activation by MarA in Escherichia coli [PDF]

, 2009
We have developed a mathematical model of transcriptional activation by MarA in Escherichia coli, and used the model to analyze measurements of MarA-dependent activity of the marRAB, sodA, and micF promoters in mar-rob- cells. The model rationalizes an unexpected poor correlation between the mid-point of in vivo promoter activity profiles and in vitro ...
arxiv   +1 more source