Results 31 to 40 of about 987,281 (377)

SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19

Expert Opinion on Therapeutic Patents, 2021
Introduction: The current SARS-CoV-2 pandemic urgently demands for both prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has no counterpart in human cells, is an excellent target for drug development.
I. Vicenti, M. Zazzi, F. Saladini
semanticscholar   +1 more source

RNA-dependent RNA polymerase of tobacco plants [PDF]

Proceedings of the National Academy of Sciences, 1978
Several properties of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) active fractions obtained from tobacco plants, be they uninfected, infected with tobacco mosaic virus, or infected with tobacco necrosis virus, were compared.
H. Fraenkel-Conrat, Machiko Ikegami
openaire   +3 more sources

6S RNA-Dependent Susceptibility to RNA Polymerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2022
Bacterial small RNAs (sRNAs) contribute to a variety of regulatory mechanisms that modulate a wide range of pathways, including metabolism, virulence, and antibiotic resistance. We investigated the involvement of sRNAs in rifampicin resistance in the opportunistic pathogen Staphylococcus aureus .
Esberard, Marick, Hallier, Marc, Liu, Wenfeng, Morvan, Claire, Bossi, Lionello, Figueroa-Bossi, Nara, Felden, Brice, Bouloc, Philippe   +7 more
openaire   +2 more sources

Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis

PLoS ONE, 2022
COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
doaj   +2 more sources

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

Journal of Medical Virology, 2020
An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase (RdRp) is an important polymerase that catalyzes the replication of RNA from ...
Jrhau Lung, Yu-Shih Lin, Yao-Hsu Yang, Yu-Lun Chou, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Ching-Yuan Wu   +7 more
semanticscholar   +1 more source

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science, 2020
A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin, W. Yin, C. Mao, Xiaodong Luan, Xiaodong Luan, D. Shen, Qingya Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuan Chao Xie, Guanghui Tian, He wei Jiang, Sheng-ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Shuyang Zhang, Yan Zhang, H. E. Xu   +24 more
semanticscholar   +1 more source

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. [PDF]

PLoS ONE, 2014
Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp).
Romina Croci, Margherita Pezzullo, Delia Tarantino, Mario Milani, Shwu-Chen Tsay, Radhakrishnan Sureshbabu, Yi-Jin Tsai, Eloise Mastrangelo, Jacques Rohayem, Martino Bolognesi, Jih Ru Hwu   +10 more
doaj   +1 more source

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Science, 2021
Mind your metals Iron–sulfur clusters are important cofactors for proteins involved in metabolism and electron transfer but are also sometimes found in enzymes involved in transcription and replication of DNA.
N. Maio, B. Lafont, Debangsu Sil, Yan Li, J. Bollinger, C. Krebs, T. Pierson, W. Linehan, T. Rouault   +8 more
semanticscholar   +1 more source

RNA-dependent RNA polymerases of plants [PDF]

Proceedings of the National Academy of Sciences, 1979
The existence of RNA-dependent RNA polymerases (EC 2.7.7.48) in plants has been definitely proven by their isolation in pure form from cucumber and tobacco in our laboratory and from cowpea at Wageningen. These enzymes are single-chain proteins of 100-130 kilodaltons. They show clear physical and biochemical differences characteristic for a given plant
openaire   +4 more sources

The Functions of RNA-Dependent RNA Polymerases in Arabidopsis [PDF]

The Arabidopsis Book, 2011
One recently identified mechanism that regulates mRNA abundance is RNA silencing, and pioneering work in Arabidopsis thaliana and other genetic model organisms helped define this process. RNA silencing pathways are triggered by either self-complementary fold-back structures or the production of double-stranded RNA (dsRNA) that gives rise to small RNAs (
Brian D. Gregory, Matthew R. Willmann, Matthew W. Endres, Rebecca T. Cook   +3 more
openaire   +3 more sources