Results 31 to 40 of about 965,759 (346)
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective
Journal of Biomolecular Structure and Dynamics, 2020 New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections.
Abdo A. Elfiky
semanticscholar +1 more source
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
Expert Opinion on Therapeutic Patents, 2021 Introduction: The current SARS-CoV-2 pandemic urgently demands for both prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has no counterpart in human cells, is an excellent target for drug development.
I. Vicenti, M. Zazzi, F. Saladini
semanticscholar +1 more source
Density- and elongation speed-dependent error correction in RNA polymerization [PDF]
, 2021 Backtracking of RNA polymerase (RNAP) is an important pausing mechanism during DNA transcription that is part of the error correction process that enhances transcription fidelity. We model the backtracking mechanism of RNA polymerase, which usually happens when the polymerase tries to incorporate a mismatched nucleotide triphosphate.
arxiv +1 more source
The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
Journal of Medical Virology, 2020 An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase (RdRp) is an important polymerase that catalyzes the replication of RNA from ...
Jrhau Lung +7 more
semanticscholar +1 more source
PLoS ONE, 2022 COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
doaj +2 more sources
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Science, 2020 A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin +24 more
semanticscholar +1 more source
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
Science, 2021 Mind your metals Iron–sulfur clusters are important cofactors for proteins involved in metabolism and electron transfer but are also sometimes found in enzymes involved in transcription and replication of DNA.
N. Maio +8 more
semanticscholar +1 more source
The Functions of RNA-Dependent RNA Polymerases in Arabidopsis [PDF]
The Arabidopsis Book, 2011 One recently identified mechanism that regulates mRNA abundance is RNA silencing, and pioneering work in Arabidopsis thaliana and other genetic model organisms helped define this process. RNA silencing pathways are triggered by either self-complementary fold-back structures or the production of double-stranded RNA (dsRNA) that gives rise to small RNAs (
Brian D. Gregory +3 more
openaire +3 more sources
Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. [PDF]
PLoS ONE, 2014 Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp).
Romina Croci +10 more
doaj +1 more source
Ribovirus classification by a polymerase barcode sequence [PDF]
PeerJ, 2022 RNA viruses encoding a polymerase gene (riboviruses) dominate the known eukaryotic virome. High-throughput sequencing is revealing a wealth of new riboviruses known only from sequence, precluding classification by traditional taxonomic methods.
Artem Babaian, Robert Edgar
doaj +2 more sources