Results 61 to 70 of about 987,281 (377)
A narnavirus-like element from the trypanosomatid protozoan parasite Leptomonas seymouri [PDF]
, 2016 Genome sequences were determined for a novel RNA virus, Leptomonas seymouri Narna-like virus 1 (LepseyNLV1). A 2.9-kb segment encodes an RNA-dependent RNA polymerase (RdRp), while a smaller 1.5-kb segment showed no database search matches.
Akopyants, Natalia S +3 more
core +2 more sources
A comparison of viral RNA-dependent RNA polymerases
Current Opinion in Structural Biology, 2006 Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain ...
Ferrer-Orta, Cristina +3 more
openaire +4 more sources
Journal of Physical Chemistry B, 2020 Starting from late 2019, the coronavirus disease 2019 (COVID-19) has emerged as a once-in-a-century pandemic with deadly consequences, which urgently calls for new treatments, cures, and supporting apparatuses.
Leili Zhang, R. Zhou
semanticscholar +1 more source
RNA-dependent RNA polymerases of dsRNA bacteriophages
Virus Research, 2004 Genome replication and transcription of riboviruses are catalyzed by an RNA-dependent RNA polymerase (RdRP). RdRPs are normally associated with other virus- or/and host-encoded proteins that modulate RNA polymerization activity and template specificity. The polymerase complex of double-stranded dsRNA viruses is a large icosahedral particle (inner core)
Makeyev, E, Grimes, J
openaire +4 more sources
Selection of single-chain antibodies that specifically interact with vesicular stomatitis virus (VSV) nucleocapsid and inhibit viral RNA synthesis. [PDF]
, 2005 International audienceThe RNA genome of non-segmented negative-strand RNA viruses is completely covered by the nucleoprotein (N) forming a ribonucleoprotein complex, the nucleocapsid.
Cortay, Jean-Claude +2 more
core +3 more sources
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B
Viruses, 2010 More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill +2 more
doaj +1 more source
The murine norovirus core subgenomic RNA promoter consists of a stable stem-loop that can direct accurate initiation of RNA synthesis. [PDF]
, 2014 UNLABELLED: All members of the Caliciviridae family of viruses produce a subgenomic RNA during infection. The subgenomic RNA typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subgenomic RNA also encodes the ...
Bailey, Dalan +9 more
core +1 more source
Frontiers in Microbiology, 2022 RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai +12 more
doaj +1 more source
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
core +2 more sources
Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]
, 2020 Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G. +10 more
core +1 more source