A comparison of viral RNA-dependent RNA polymerases
Current Opinion in Structural Biology, 2006 Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain ...
Ferrer-Orta, Cristina +3 more
openaire +4 more sources
Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes
Molecules, 2021 The work is devoted to the study of the complementarity of the electronic structures of the ligands and SARS-CoV-2 RNA-dependent RNA polymerase. The research methodology was based on determining of 3D maps of electron densities of complexes using an ...
Nadezhda Palko +2 more
doaj +1 more source
Mechanical Properties of Transcription [PDF]
Phys. Rev. Lett. 118, 268101 (2017), 2016 Recently the physical characterization of a number of biological processes has proven indispensable for a full understanding of natural phenomena. One such example is the mechanical properties of transcription, which have been shown to have significant effects in gene expression.
arxiv +1 more source
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease [PDF]
, 2002 The complete nucleotide sequence of an ophiovirus associated with lettuce big-vein disease has been elucidated. The genome consisted of four RNA molecules of approximately 7ò8, 1ò7, 1ò5 and 1ò4 kb.
Dullemans, A.M. +3 more
core +2 more sources
RNA-dependent RNA polymerases of dsRNA bacteriophages
Virus Research, 2004 Genome replication and transcription of riboviruses are catalyzed by an RNA-dependent RNA polymerase (RdRP). RdRPs are normally associated with other virus- or/and host-encoded proteins that modulate RNA polymerization activity and template specificity. The polymerase complex of double-stranded dsRNA viruses is a large icosahedral particle (inner core)
Makeyev, E, Grimes, J
openaire +4 more sources
Journal of Physical Chemistry B, 2020 Starting from late 2019, the coronavirus disease 2019 (COVID-19) has emerged as a once-in-a-century pandemic with deadly consequences, which urgently calls for new treatments, cures, and supporting apparatuses.
Leili Zhang, R. Zhou
semanticscholar +1 more source
The DNA/RNA-Dependent RNA Polymerase QDE-1 Generates Aberrant RNA and dsRNA for RNAi in a Process Requiring Replication Protein A and a DNA Helicase [PDF]
, 2010 The Neurospora RNA-dependent RNA polymerase QDE-1 is an RNA polymerase that can use both RNA and DNA as templates, suggesting a new mechanism for small RNA ...
A Kapoor +59 more
core +5 more sources
Non-processive transcription of poly[d(A—T)] by wheat germ RNA polymerase II [PDF]
, 1982 RNA product distribution obtained during the transcription of poly[d(A—T)] by wheat germ RNA polymerase IIA under various experimental conditions was analyzed by high resolution polyacrylamide gel electrophoresis.
Durand, Robert +3 more
core +1 more source
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B
Viruses, 2010 More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill +2 more
doaj +1 more source
Uncovering the effect of RNA polymerase steric interactions on gene expression noise: analytical distributions of nascent and mature RNA numbers [PDF]
arXiv, 2023 The telegraph model is the standard model of stochastic gene expression, which can be solved exactly to obtain the distribution of mature RNA numbers per cell. A modification of this model also leads to an analytical distribution of the nascent RNA numbers. These solutions are routinely used for the analysis of single-cell data, including the inference
arxiv