Results 71 to 80 of about 965,759 (346)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad, Saima Ikram, Fawad Ahmad, Irshad Ur Rehman, Maryam Mushtaq   +4 more
doaj  

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

Virology Journal, 2007
Background Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases.
Vaccaro Joseph A, Freistadt Marion S, Eberle Karen E   +2 more
doaj   +1 more source

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Frontiers in Microbiology, 2022
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai, Kanasap Kaewchim, Kanasap Kaewchim, Techit Thavorasak, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra   +12 more
doaj   +1 more source

A narnavirus-like element from the trypanosomatid protozoan parasite Leptomonas seymouri [PDF]

, 2016
Genome sequences were determined for a novel RNA virus, Leptomonas seymouri Narna-like virus 1 (LepseyNLV1). A 2.9-kb segment encodes an RNA-dependent RNA polymerase (RdRp), while a smaller 1.5-kb segment showed no database search matches.
Akopyants, Natalia S, Beverley, Stephen M, Dobson, Deborah E, Lye, Lon-Fye   +3 more
core   +2 more sources

Functional lability of RNA-dependent RNA polymerases in animals

PLOS Genetics, 2018
AbstractRNA interference (RNAi) requires RNA-dependent RNA polymerases (RdRPs) in many eukaryotes, and RNAi amplification constitutes the only known function for eukaryotic RdRPs. Yet in animals, classical model organisms can elicit RNAi without possessing RdRPs, and only nematode RNAi was shown to require RdRPs.
Natalia Pinzón, Stéphanie Bertrand, Lucie Subirana, Isabelle Busseau, Hector Escrivá, Hervé Seitz   +5 more
openaire   +9 more sources

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Functional Importance of the Hydrophobic Residue 362 in Influenza A PB1 Subunit

Viruses, 2023
PB1, acting as the catalytic subunit of the influenza polymerase, has numerous sequentially and structurally conserved regions. It has been observed that the slight modification of residues in PB1 would greatly affect the polymerase activity and even ...
Johnson Jor-Shing Chan, Yun-Sang Tang, Chun-Yeung Lo, Pang-Chui Shaw   +3 more
doaj   +1 more source

A Magnetic Tweezers Study of a RNA-Dependant RNA Polymerase [PDF]

Biophysical Journal, 2012
RNA-dependent RNA Polymerases (RdRPs) are involved in the transcription and the replication of RNA genome of many viruses. The RdRP of the bacteriophage Φ6 (P2) is located inside the viral capsid where it transcribes double-stranded RNA to yield single-stranded RNA that infects the host cytosol.Here, we have studied the transcription activity of the P2
Minna M. Poranen, Martin Depken, David Dulin, Igor D. Vilfan, Susanne Hage, Wiecher Kamping, Dennis H. Bamford, Nynke H. Dekker   +7 more
openaire   +2 more sources

Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach [PDF]

International Journal of Biological Macromolecules 163 (2020) 1787-1797, 2020
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been heavily invested in the discovery of a drug to combat SARS-CoV-2. It has been found that RNA-dependent RNA Polymerase (RdRp) plays a crucial role in SARS-CoV-2 replication, and thus could be a potential drug target.
arxiv   +1 more source

Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A) [PDF]

, 1977
A template-dependent RNA polymerase has been isolated from poliovirus-infected cells by assaying for the ability of the enzyme to copy poly(A) complexed to an oligo(U) primer.
Baltimore, David, Flanegan, James B.
core