Results 91 to 100 of about 54,776 (143)

Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics

Beilstein Journal of Organic Chemistry
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process.
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evžen Bouřa, Radim Nencka   +7 more
doaj   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic. [PDF]

Viruses, 2023
Comunale BA, Larson RJ, Jackson-Ward E, Singh A, Koback FL, Engineer LD.   +5 more
europepmc   +1 more source

The Paramyxovirus Polymerase Complex as a Target for Next-Generation Anti-Paramyxovirus Therapeutics

Frontiers in Microbiology, 2015
The paramyxovirus family includes major human and animal pathogens, including measles virus, mumps virus, and human respiratory syncytial virus (RSV), as well as the emerging zoonotic Hendra and Nipah viruses.
Richard K Plemper, Robert eCox
doaj   +1 more source

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Antiviral Research, 2019
The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the ...
Ariane J. Brown, John J. Won, Rachel L. Graham, K. Dinnon, A. Sims, Joy Y. Feng, T. Cihlář, M. Denison, R. Baric, T. Sheahan   +9 more
semanticscholar   +1 more source

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +3 more
semanticscholar   +1 more source

Cryo-EM structures of Nipah virus polymerases and high-throughput biochemical RdRp assay development enable anti-NiV drug discovery [PDF]

Structural Dynamics
The transcription and replication of Nipah virus (NiV) is driven by the large protein (L) and its essential co-factor phosphoprotein (P). L encodes all the viral enzymatic functions including RNA-dependent RNA polymerase (RdRp) activity while P functions
Ahmed Rohaim, Colin Deniston, Zhenhang Chen, Cosmo Buffolo, Tiffany Tsang, Lilli Xie, Michael DiDonato, Glen Spraggon, Matt Clifton, Nadine Jarrousse, Judith Straimer, Bo Liang   +11 more
doaj   +1 more source

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source

The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)'s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19. [PDF]

Molecules, 2023
Metwally K, Abo-Dya NE, Alahmdi MI, Albalawi MZ, Yahya G, Aljoundi A, Salifu EY, Elamin G, Ibrahim MAA, Sayed Y, Fanucchi S, Soliman MES.   +11 more
europepmc   +1 more source

RNA Dependent RNA Polymerase (RdRP) [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

A BIOINFORMATICS CHARACTERIZATION OF THE RNA-DEPENDENT RNA POLYMERASE FROM THE PARASITIC FUNGI, Metarhizium anisopliae

Российский паразитологический журнал, 2016
Metarhizium anisopliae is an entomopathogenic organism that is parasitic towards insects, including those that serve as vectors for human disease, including malaria parasite infected Anopheles mosquitoes.
C. N. WEIR, E. EWONG, G. F. KING
doaj