Transferable approaches to CRISPR-Cas9 induced genome editing in non-model insects: a brief guide. [PDF]
Ahmed HMM, Zheng L, Hunnekuhl VS.
europepmc +1 more source
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz+14 more
wiley +1 more source
RNA signaling in medicinal plants: An overlooked mechanism for phytochemical regulation. [PDF]
Alum EU, Udechukwu CD, Obasi DC.
europepmc +1 more source
Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions
What if every cell line can carry an unforgeable genomic fingerprint—one that proves its origin, ensures its authenticity, and thwarts unauthorized duplication? Here, CRISPR‐induced DNA lesions paired with TdT‐mediated repair produce robust, unique, and unclonable genetic signatures—advancing the concept of molecular Physical Unclonable Functions (PUF)
Zikun Zhou+7 more
wiley +1 more source
Protocol for a minigene splice assay using the pET01 vector. [PDF]
Andreae H+7 more
europepmc +1 more source
A Single Subunit from Avian Myeloblastosis Virus with Both RNA-Directed DNA Polymerase and Ribonuclease H Activity [PDF]
Duane P. Grandgenett+2 more
openalex +1 more source
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing(WGS) and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang+8 more
wiley +1 more source
Mutation- and Transcription-Driven Omic Burden of Daptomycin/Dalbavancin-R and Glycopeptide-RS Fitness Costs in High-Risk MRSA: A Nexus in Antimicrobial Resistance Mechanisms-Genome Proneness-Compensatory Adaptations. [PDF]
Chines E+4 more
europepmc +1 more source
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen+12 more
wiley +1 more source
Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance. [PDF]
Chen ZJ.
europepmc +1 more source