Results 31 to 40 of about 325,869 (333)

Inhibition of RNA-directed DNA polymerase by aurintricarboxylic acid.

Nucleic Acids Research, 1976
Commercial-grade aurintricarboxylic acid (ATA) inhibits poly(A), poly(C) and viral RNA-directed DNA synthesis by detergent-disrupted virions of Moloney murine leukemia virus. Paper chromatography of crude ATA yields two active components, which appear to behave identically, and at least two inactive components.
J F, Givens, K F, Manly
openaire   +3 more sources

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors [PDF]

, 2005
RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture.
Fisher, Timothy S, Joshi, Pheroze, Prasad, Vinayaka R   +2 more
core   +3 more sources

Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase

Scientific Reports, 2022
In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of ...
Shuntaro Takahashi, Saki Matsumoto, Pallavi Chilka, Saptarshi Ghosh, Hiromichi Okura, Naoki Sugimoto   +5 more
doaj   +1 more source

Effect of UV Light on RNA-Directed DNA Polymerase Activity of Murine Oncornaviruses [PDF]

Journal of Virology, 1975
The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 × 10 4 to 3.1 × 10 4 ergs/mm 2 .
G G, Lovinger, H P, Ling, R V, Gilden, M, Hatanaka   +3 more
openaire   +2 more sources

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

Pol IV-Dependent siRNA Production is Reduced in Brassica rapa

Biology, 2013
Plants produce a diverse array of small RNA molecules capable of gene regulation, including Pol IV-dependent short interfering (p4-si)RNAs that trigger transcriptional gene silencing.
Rebecca A. Mosher, Yi Huang, Timmy Kendall   +2 more
doaj   +1 more source

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity

Biology, 2012
HIV-1 enzyme reverse transcriptase (RT) is a major target for antiviral drug development, with over half of current FDA-approved therapeutics against HIV infection targeting the DNA polymerase activity of this enzyme. HIV-1 RT is a multifunctional enzyme
Michael A. Parniak, Stefan G. Sarafianos, Rieko Ishima, Krystal LaBarge, Tatiana Ilina   +4 more
doaj   +1 more source

Unwinding-like activity associated with avian retrovirus RNA-directed DNA polymerase [PDF]

Journal of Virology, 1978
The avian retrovirus RNA-directed DNA polymerase contains an activity that is capable of removing hydrogen bonds from duplex nucleic acid molecules. This "unwinding-like" activity appears to be specific in its action, affecting RNA.DNA and DNA.DNA duplex molecules but not RNA.RNA duplexes.
M S, Collett, J P, Leis, M S, Smith, A J, Faras   +3 more
openaire   +2 more sources

RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus [PDF]

, 2011
Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentially ...
A Bakos, A Bell, A Dey, A Lin, AI Bell, B Kempkes, B Sugden, BM Peterlin, C Lee, CD Gregory, CF Bourgeois, CH Wu, CH Wu, D Ivanov, DA Gilchrist, DC Hargreaves, DS Gilmour, DS Gilmour, DY Wu, DY Wu, E Johannsen, E Klein, EA Abbate, G Kelly, G Laux, H Gross, H Kirby, Helen M. Webb, I Tempera, J You, JH Yik, JI Cohen, K Fujinaga, KD Robertson, KD Robertson, L Waltzer, L Wang, M Ottinger, M Woisetschlaeger, M Woisetschlaeger, Michelle J. West, MJ West, MK Jang, N Alazard, N Kaplan, NA Brown, NF Marshall, NP Gomes, P Filippakopoulos, Paul M. Lieberman, R Tierney, Richard D. Palermo, S Egloff, S Egloff, S Swaminathan, SH Chao, SJ Bark-Jones, SR Grossman, SY Wu, T Fujita, T Fujita, T Henkel, T Wada, T Wada, U Zimber-Strobl, VT Nguyen, W Lucchesi, W Yue, W Yue, W Yue, W Zhu, X Tong, X Tong, X Tong, YK Kim, Z Yang   +75 more
core   +3 more sources

On the origin of DNA genomes: evolution of the division of labor between template and catalyst in model replicator systems. [PDF]

PLoS Computational Biology, 2011
The division of labor between template and catalyst is a fundamental property of all living systems: DNA stores genetic information whereas proteins function as catalysts. The RNA world hypothesis, however, posits that, at the earlier stages of evolution,
Nobuto Takeuchi, Paulien Hogeweg, Eugene V Koonin   +2 more
doaj   +1 more source