Results 221 to 230 of about 224,288 (284)
HIV-1 Tat: Molecular Switch in Viral Persistence and Emerging Technologies for Functional Cure. [PDF]
Yu K, Liu H, Pan T.
europepmc +1 more source
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang+15 more
wiley +1 more source
RNA signaling in medicinal plants: An overlooked mechanism for phytochemical regulation. [PDF]
Alum EU, Udechukwu CD, Obasi DC.
europepmc +1 more source
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang+8 more
wiley +1 more source
RNA Binding Motif Protein 15 (RBM15): Structure, Function and Its Research Progress in Tumors. [PDF]
Long X, Hu B, Zhu S, Wu Y, Wang T.
europepmc +1 more source
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang+7 more
wiley +1 more source
Emerging Nanotechnology Strategies for Obesity Therapy
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang+5 more
wiley +1 more source
The Valsa mali Effector VmSR1 Accelerates the Degradation of Tudor-SN2 to Suppress RNA Silencing and Plant Immunity. [PDF]
Jiang T+5 more
europepmc +1 more source
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen+9 more
wiley +1 more source
Dapagliflozin alleviates mitochondrial damage in the myocardium under diabetic conditions by targeting sortilin. [PDF]
Gao Y+8 more
europepmc +1 more source