Results 161 to 170 of about 3,122,867 (388)
Translational control by the multi-KH domain protein Scp160 [PDF]
, 2010 The control of mRNA translation mediated by RNA-binding proteins (RBPs) is a key player in modulating gene expression. In S. cerevisiae, the multi-KH domain protein Scp160 associates with a large number of mRNAs and is present on membrane-bound and, to a
Schreck, Heidrun
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Nature CommunicationsRNA-binding proteins are central for many biological processes and their characterization has demonstrated a broad range of functions as well as a wide spectrum of target structures.
Johanna Luige +3 more
doaj +1 more source
RNA binding proteins in cancer chemotherapeutic drug resistance
Frontiers in Cell and Developmental BiologyDrug resistance has been a major obstacle in the quest for a cancer cure. Many chemotherapeutic treatments fail to overcome chemoresistance, resulting in tumor remission.
Hemanathan Vembuli +7 more
doaj +1 more source
An in vitro technique to identify the RNA binding-site sequences for RNA-binding proteins
BioTechniques, 2017 RNA–protein interactions play a major role in gene regulation. Although many techniques to analyze RNA–protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain ...
SunKyung Choi +3 more
doaj +1 more source
Identification of RNA-Binding Protein Targets with HyperTRIBE in Saccharomyces cerevisiae [PDF]
, 2023 Weilan Piao +8 more
openalex +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Extracellular Vesicles: Tiny Messengers for Mighty RNA Delivery
BiologicsExtracellular vesicles (EVs) encompass a diverse array of cell-derived vesicles, originating either from the endosomal compartment (exosomes) or generated through shedding from the cell membrane.
Alakesh Das
doaj +1 more source
NEAT1 Scaffolds RNA Binding Proteins and the Microprocessor to Globally Enhance Pri-miRNA Processing
Nature Structural &Molecular Biology, 2017 MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs.
Li Jiang +12 more
semanticscholar +1 more source