Results 181 to 190 of about 3,122,867 (388)

Targeting RNA‐binding proteins for cancer therapy

Clinical and Translational Discovery, 2023
Chengpiao Lu, Guoqiang Xu, Jingjing Ma
doaj   +1 more source

Thermodynamic Analysis of a Multifunctional RNA-Binding Protein, <i>Pho</i>Rpp38, in the Hyperthermophilic Archaeon <i>Pyrococcus horikoshii</i> OT3 [PDF]

, 2012
Kosuke Oshima, Takashi Nakashima, Yoshimitsu Kakuta, Kouhei Tsumoto, Makoto Kimura   +4 more
openalex   +1 more source

Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning

Nature Biotechnology, 2015
Babak Alipanahi, Andrew Delong, M. Weirauch, B. Frey   +3 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Complementation of Vaccinia Virus Lacking the Double-Stranded RNA-Binding Protein Gene E3L by Human Cytomegalovirus

, 2002
Stephanie J. Child, Sohail Jarrahian, Victoria M. Harper, Adam P. Geballe   +3 more
openalex   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Alleviation of Human Papillomavirus E2-Mediated Transcriptional Repression via Formation of a TATA Binding Protein (or TFIID)-TFIIB-RNA Polymerase II-TFIIF Preinitiation Complex

, 2000
Samuel Y. Hou, Shwu-Yuan Wu, Tianyuan Zhou, Mary C. Thomas, Cheng-Ming Chiang   +4 more
openalex   +1 more source

PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate [PDF]

, 2023
Jimei Xu, Yanwen Jiang, Ryan Sherrard, Kyoko Ikegami, Barbara Conradt   +4 more
openalex   +1 more source

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Molecules and Cells, 2015
Yuan Lin, David S. W. Protter, M. Rosen, R. Parker   +3 more
semanticscholar   +1 more source