Results 211 to 220 of about 1,122,786 (246)

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

Orchestrating Nutrient Homeostasis: RNA-Binding Proteins as Molecular Conductors in Metabolic Disease Pathogenesis. [PDF]

Nutrients
Sun S, Li X, Zhai J, Lu C, Yu W, Wu W, Chen J.   +6 more
europepmc   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins. [PDF]

J Cell Biol
Hasegawa-Ogawa M, Onda-Ohto A, Nakajo T, Funabashi A, Ohya A, Yazaki R, Okano HJ.   +6 more
europepmc   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response. [PDF]

Plants (Basel)
Wang T, Meng K, Zhu Z, Pan L, Okita TW, Zhang L, Tian L.   +6 more
europepmc   +1 more source

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

Arafat M, Gotea V, Umar MI, Muharram A, Kamhi E, Agami R, Sperling J, Hafner M, Elnitski L, Sperling R.   +9 more
europepmc   +1 more source

Review of roles of RNA-binding proteins on NAFLD and the related pharmaceutical measures. [PDF]

Biomol Biomed
Li C, Yang F, Yuan Z, Wei X.
europepmc   +1 more source

Nuclear RNA-binding proteins meet cytoplasmic viruses. [PDF]

RNA
Castello A, Kamel W.
europepmc   +1 more source

ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation. [PDF]

EMBO J
Watanabe Y, Suzuki N, Nakagawa T, Hosogane M, Akiyama T, Kageyama N, Funayama Y, Warita H, Morimoto S, Okano H, Aoki M, Nakayama K.   +11 more
europepmc   +1 more source