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The RNA of unfertilized sea urchin eggs is ‘capped’
Cell Differentiation, 1977It is shown that the RNA of unfertilized sea urchin eggs is active in stimulating protein synthesis in a wheat germ cell free system. This activity is not lowered by conditions that inhibit the methylation processes but is inhibited by a treatment that damages the "cap", A difference in activity in a wheat germ cell free system between the RNA of ...
A M, Pirrone +4 more
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Potential Therapeutic Applications of Rna Cap Analogs
Future Medicinal Chemistry, 2013Cap analogs are chemically modified derivatives of the unique cap structure present at the 5´ end of all eukaryotic mRNAs and several non-coding RNAs. Until recently, cap analogs have served primarily as tools in the study of RNA metabolism. Continuing advances in our understanding of cap biological functions (including RNA stabilization, pre-mRNA ...
Marcin, Ziemniak +3 more
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[Capping strategies in RNA viruses].
Medecine sciences : M/S, 2012Most viruses use the mRNA-cap dependent cellular translation machinery to translate their mRNAs into proteins. The addition of a cap structure at the 5' end of mRNA is therefore an essential step for the replication of many virus families. Additionally, the cap protects the viral RNA from degradation by cellular nucleases and prevents viral RNA ...
Mickaël, Bouvet +7 more
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‘Cap’ structures in maize poly(A)-containing RNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979Poly(A)-containing RNA was isolated from maize embryos by chromatography on columns of oligo(dT)-cellulose and exhaustively digested with ribonucleases T2, T1, and A. Fractionation of the digests by two-dimensional electrophoresis revealed the presence of three 7-methylguanosine-terminated 'cap structures' of the type m7GpppNp.
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Priming of Influenza Viral RNA Transcription by Capped Heterologous RNAs
1981Influenza virus is a negative-stranded RNA virus, i.e., the viral messenger RNA (mRNA) is complementary to the genome RNA (which is segmented), and the virion contains the enzyme system which transcribes the genome RNA into the viral mRNA. This virus employs a unique mechanism for the initiation of the synthesis of its mRNA.
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Viral RNA capping: Mechanisms and antiviral therapy
Journal of Medical VirologyAbstractRNA capping is an essential trigger for protein translation in eukaryotic cells. Many viruses have evolved various strategies for initiating the translation of viral genes and generating progeny virions in infected cells via synthesizing cap structure or stealing the RNA cap from nascent host messenger ribonucleotide acid (mRNA). In addition to
Saini Chen +5 more
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Noncanonical metabolite RNA caps: Classification, quantification, (de)capping, and function
Wiley Interdisciplinary Reviews RNA, 2022Johanna Mattay
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Discovery, Processing, and Potential Role of Noncanonical Caps in RNA
RNA Technologies, 2021Nora Flynn, Xuemei Chen
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Captivating Perplexities of Spinareovirinae 5′ RNA Caps
Viruses, 2021Maya Shmulevitz, Shmulevitz Maya
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