Results 71 to 80 of about 1,426,666 (312)

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Arabidopsis Disulfide Reductase, Trx-h2, Functions as an RNA Chaperone under Cold Stress

Applied Sciences, 2021
The thioredoxin-h (Trx-h) family of Arabidopsis thaliana comprises cytosolic disulfide reductases. However, the physiological function of Trx-h2, which contains an additional 19 amino acids at its N-terminus, remains unclear.
Eun Seon Lee, Joung Hun Park, Seong Dong Wi, Ho Byoung Chae, Seol Ki Paeng, Su Bin Bae, Kieu Anh Thi Phan, Sang Yeol Lee   +7 more
doaj   +1 more source

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Structure and Dynamics of the Unassembled Nucleoprotein of Rabies Virus in Complex with Its Phosphoprotein Chaperone Module

Viruses, 2022
As for all non-segmented negative RNA viruses, rabies virus has its genome packaged in a linear assembly of nucleoprotein (N), named nucleocapsid. The formation of new nucleocapsids during virus replication in cells requires the production of soluble N ...
Francine C. A. Gérard, Jean-Marie Bourhis, Caroline Mas, Anaïs Branchard, Duc Duy Vu, Sylvia Varhoshkova, Cédric Leyrat, Marc Jamin   +7 more
doaj   +1 more source

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]

, 2015
Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya, Cicardi, Maria Elena, Crippa, Valeria, Cristofani, Riccardo, Galbiati, Mariarita, Giorgetti, Elisa, Lieberman, Andrew P., Meroni, Marco, Messi, Elio, Milioto, Carmelo, Pennuto, Maria, Piccolella, Margherita, Polanco, Maria Josefa, Poletti, Angelo, Rocchi, Anna, Rusmini, Paola   +15 more
core   +2 more sources

Role of RNA chaperones in virus replication

Virus Research, 2009
RNA molecules are functionally diverse in part due to their extreme structural flexibility that allows rapid regulation by refolding. RNA folding could be a difficult process as often molecules adopt a spatial conformation that is very stable but not biologically functional, named a kinetic trap.
Zuniga, Sonia, Sola, Isabel, Cruz, Jazmina L. G., Enjuanes, Luis   +3 more
openaire   +4 more sources

Directed motion emerging from two coupled random processes: Translocation of a chain through a membrane nanopore driven by binding proteins

, 2005
We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer through the pore.
Alberts B, Ambjörnsson T, Ambjörnsson T, Bates M, Chauwin J-F, Elston T C, Elston T C, Farkas Z, Gardiner C W, Gerland U, Harada Y, Lubensky D K, McQuistan R B, Meller A, Metzler R, Metzler R, Michael A Lomholt, Peskin C S, Press W H, Ralf Metzler, Risken H, Simon S F, Tobias Ambjörnsson, van Kampen N G   +23 more
core   +2 more sources

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner, P. J. Hart, J. P. Cook, P. Pietroni, C. Rogon, J. Hohfeld, L. M. Roberts, J. M. Lord, Brodsky, Meusser, Spooner, Wesche, Argent, van Deurs, Rapak, Wales, Meacham, Brodsky, Hudson, Roe, Lawson, Argent, Savino, Chaddock, Chen, Luders, H  hfeld, Urushitani, Younger, Arndt, Nakatsukasa, Nakatsukasa, Hundley   +32 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]

, 2015
Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R, Fangue, Nann A, May, Bernie P, Meek, Mariah H, Rincón, Gonzalo, Stephens, Molly R, Tomalty, Katharine MH   +6 more
core