Results 81 to 90 of about 1,426,666 (312)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy

Journal of Virology
Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae family, is a single-stranded, positive-sense RNA virus. Heat shock protein A1 (HSPA1) has been shown to influence the entry, translation, assembly, and release of enterovirus A71 (EV-A71)
Mei Ren, Haiqian Zhou, Jin-en Wu, Jia-ning Wang, Xuefei Wang, Sahibzada Waheed Abdullah, Huichen Guo, Shiqi Sun   +7 more
doaj   +1 more source

dTrmt10A impacts Hsp70 chaperone m6A levels and the stress response in the Drosophila brain

Scientific Reports, 2023
Chronic cellular stress has a profound impact on the brain, leading to degeneration and accelerated aging. Recent work has revealed the vital role of RNA modifications, and the proteins responsible for regulating them, in the stress response.
Alexandra E. Perlegos, Xiuming Quan, Kirby M. Donnelly, Hui Shen, Emily J. Shields, Heidi Elashal, Kathy Fange Liu, Nancy M. Bonini   +7 more
doaj   +1 more source

T3SS chaperone of the CesT family is required for secretion of the anti-sigma factor BtrA in Bordetella pertussis

Emerging Microbes and Infections, 2023
Bordetella pertussis is a Gram-negative, strictly human re-emerging respiratory pathogen and the causative agent of whooping cough. Similar to other Gram-negative pathogens, B.
Jakub Držmíšek, Denisa Petráčková, Ana Dienstbier, Ivana Čurnová, Branislav Večerek   +4 more
doaj   +1 more source

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]

, 2015
Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin, Brady, Cantley, Caputo, Carnero, Cornwall, Cuervo, Cuervo, De Strooper, Debnath, Denk, Deutsch, Dikic, Djavaheri-Mergny, Eckert, Esposito, Facchiano, Fesus, Graham, Griffin, Griffin, Ha, Han, Johansen, Johansen, Ju, Khosla, Khosla, Komatsu, Kumar, Ledesma, Lenz, Levine, Levine, Liao, Liu, Lopez-Berestein, Mazurek, Mehta, Murphy, Ortona, Ozpolat, Palmieri, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Piacentini, Rao, Rice, Rodolfo, Saito, Semenza, Semenza, Tavernarakis, Wang, Wang, White   +61 more
core   +2 more sources

The unusual glycine-rich C terminus of the Acinetobacter baumannii RNA chaperone Hfq plays an important role in bacterial physiology

Journal of Biological Chemistry, 2018
Acinetobacter baumannii is a Gram-negative nosocomial pathogen that causes soft tissue infections in patients who spend a long time in intensive care units.
Atin Sharma, V. Dubey, Rajnikant Sharma, Kuldip Devnath, V. Gupta, Jawed Akhter, Timsy Bhando, Aparna Verma, K. Ambatipudi, M. Sarkar, R. Pathania   +10 more
semanticscholar   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

444 Post-translational role of RNA modifications in sRNA chaperone Hfq

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: The goal of this study is to determine the role of the tRNA modifications in the translation of Hfq. Hfq is an RNA chaperone that acts as a co-factor for the action of the largest class of small RNAs in E. coli.
Jalisa Nurse, Aubee Joseph, Karl M Thompson   +2 more
doaj   +1 more source

Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins [PDF]

, 2018
The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing
Caliendo, Giuseppe, Carraro, Caterina, Corvino, Angela, Di Vaio, Paola, Fabris, Dan, Fiorino, Ferdinando, Frecentese, Francesco, Gamba, Elia, Gatto, Barbara, Kenderdine, Thomas, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Severino, Beatrice, Sosic, Alice, Spada, Valentina   +16 more
core   +2 more sources

The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets

Nucleic Acids Research, 2017
Non-coding RNAs have critical roles in biological processes, and RNA chaperones can promote their folding into the native shape required for their function.
Ana Vakiloroayaei, N. Shah, M. Oeffinger, M. Bayfield   +3 more
semanticscholar   +1 more source