Results 1 to 10 of about 1,912,865 (328)

A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies [PDF]

Nature Communications
RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake, Leslie Watkins, Yang Liu, Takanari Inoue, Bin Wu   +4 more
doaj   +3 more sources

UPF1-Mediated RNA Decay—Danse Macabre in a Cloud [PDF]

Biomolecules, 2020
Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1.
Daria Lavysh, Gabriele Neu-Yilik
doaj   +3 more sources

The nucleolus is the site for inflammatory RNA decay during infection. [PDF]

Nat Commun, 2022
Inflammatory cytokines are key signaling molecules that can promote an immune response, thus their RNA turnover must be tightly controlled during infection.
Lee TA, Han H, Polash A, Cho SK, Lee JW, Ra EA, Lee E, Park A, Kang S, Choi JL, Kim JH, Lee JE, Min KW, Yang SW, Hafner M, Lee I, Yoon JH, Lee S, Park B.   +18 more
europepmc   +2 more sources

LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei. [PDF]

Nat Commun, 2023
Epigenetic reprogramming of the parental genome is essential for zygotic genome activation and subsequent embryo development in mammals. Asymmetric incorporation of histone H3 variants into the parental genome has been observed previously, but the ...
Zhu J, Chen K, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S, Kang L.   +12 more
europepmc   +2 more sources

RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. [PDF]

PLoS Pathogens, 2018
Exonuclease-mediated RNA decay in plants is known to be involved primarily in endogenous RNA degradation, and several RNA decay components have been suggested to attenuate RNA silencing possibly through competing for RNA substrates.
Fangfang Li, Aiming Wang
doaj   +2 more sources

Technologies for Targeted RNA Degradation and Induced RNA Decay. [PDF]

Chem Rev
The vast majority of the human genome codes for RNA, but RNA-targeting therapeutics account for a small fraction of approved drugs. As such, there is great incentive to improve old and develop new approaches to RNA targeting.
Mikutis S, Bernardes GJL.
europepmc   +2 more sources

In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay [PDF]

Bio-Protocol, 2019
The kinase/RNase IRE1 is a key effector of the cellular response to endoplasmic reticulum stress. The RNase activity of IRE1 can be measured in cells or in the test tube.
G. Karagöz, Jirka Peschek, Peter Walter, Diego Acosta-Alvear   +3 more
doaj   +2 more sources

Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli [PDF]

Molecular Systems Biology, 2015
An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Huiyi Chen, Katsuyuki Shiroguchi, Hao Ge, Xiaoliang Sunney Xie   +3 more
doaj   +3 more sources

Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. [PDF]

Nat Commun, 2022
Maternal RNA degradation is critical for embryogenesis and is tightly controlled by maternal RNA-binding proteins. Fragile X mental-retardation protein (FMR1) binds target mRNAs to form ribonucleoprotein (RNP) complexes/granules that control various ...
Zhang G, Xu Y, Wang X, Zhu Y, Wang L, Zhang W, Wang Y, Gao Y, Wu X, Cheng Y, Sun Q, Chen D.   +11 more
europepmc   +2 more sources

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +3 more sources