Results 11 to 20 of about 206,980 (316)

RNA decay and RNA silencing in plants: competition or collaboration? [PDF]

Frontiers in Plant Science, 2011
Initiation of RNA polymerase II transcription signals the beginning of a series of physically and functionally coupled pre-mRNA processing events that transform an RNA transcript into a highly structured, mature ribonucleoprotein complex.
Michael eChristie, Christopher Andrew Brosnan, Joseph Attila Rothnagel, Bernard John Carroll   +3 more
doaj   +5 more sources

RNA virus evasion of nonsense-mediated decay.

PLoS Pathogens, 2018
Nonsense-mediated decay (NMD) is a host RNA control pathway that removes aberrant transcripts with long 3' untranslated regions (UTRs) due to premature termination codons (PTCs) that arise through mutation or defective splicing.
Jared P May, Xuefeng Yuan, Erika Sawicki, Anne E Simon   +3 more
doaj   +5 more sources

Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells [PDF]

Frontiers in Endocrinology
IntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components.
Seyed M. Ghiasi, Seyed M. Ghiasi, Seyed M. Ghiasi, Piero Marchetti, Lorenzo Piemonti, Jens H. Nielsen, Bo T. Porse, Bo T. Porse, Bo T. Porse, Thomas Mandrup-Poulsen, Guy A. Rutter, Guy A. Rutter, Guy A. Rutter   +12 more
doaj   +2 more sources

Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs. [PDF]

PLoS Genetics, 2015
The human nuclear poly(A)-binding protein PABPN1 has been implicated in the decay of nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by stimulating poly(A)-polymerases (PAPα/γ), but this activity has not previously been ...
Stefan M Bresson, Olga V Hunter, Allyson C Hunter, Nicholas K Conrad   +3 more
doaj   +3 more sources

RNA uridylation and decay in plants [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2018
RNA uridylation consists of the untemplated addition of uridines at the 3′ extremity of an RNA molecule. RNA uridylation is catalysed by terminal uridylyltransferases (TUTases), which form a subgroup of the terminal nucleotidyltransferase family, to which poly(A) polymerases also belong. The key role of RNA uridylation is to regulate RNA degradation in
Caroline De Almeida, Hélène Scheer, Anthony Gobert, Veronica Fileccia, Federico Martinelli, Hélène Zuber, Dominique Gagliardi   +6 more
openalex   +5 more sources

Technologies for Targeted RNA Degradation and Induced RNA Decay. [PDF]

Chem Rev
The vast majority of the human genome codes for RNA, but RNA-targeting therapeutics account for a small fraction of approved drugs. As such, there is great incentive to improve old and develop new approaches to RNA targeting. For many RNA targeting modalities, just binding is not sufficient to exert a therapeutic effect; thus, targeted RNA degradation ...
Mikutis S, Bernardes GJL.
europepmc   +3 more sources

RNA decay in processing bodies is indispensable for adipogenesis. [PDF]

Cell Death Dis, 2021
AbstractThe RNA decay pathway plays key regulatory roles in cell identities and differentiation processes. Although adipogenesis is transcriptionally and epigenetically regulated and has been thoroughly investigated, how RNA metabolism that contributes to the stability of phenotype-shaping transcriptomes participates in differentiation remains elusive.
Maeda R, Kami D, Shikuma A, Suzuki Y, Taya T, Matoba S, Gojo S.   +6 more
europepmc   +6 more sources

DEAD-Box RNA Helicases in Gram-Positive RNA Decay

, 2012
DEAD-box RNA helicases are important players in eukaryotic and bacterial RNA metabolism. A helicase from Staphylococcus aureus was recently shown to affect RNA decay, most likely via its interaction with the proposed Gram-positive degradosome. Some, but not all, RNAs are stabilized when the helicase CshA is mutated, and among the affected RNAs is the ...
Peter Redder, Patrick Linder
openalex   +6 more sources

SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome

RNA Biology, 2023
Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes.
Soraya I. Shehata, Roy Parker
doaj   +1 more source

RNA helicases in RNA decay [PDF]

Biochemical Society Transactions, 2018
RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
openaire   +4 more sources