Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress [PDF]
eLifeCells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar +9 more
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]
Nature Communications, 2017 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached +3 more
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The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes [PDF]
Journal of Biomedical ScienceBackground The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats flavivirus infections through the 5′
Ren-Jye Lin +5 more
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PLoS Pathogens, 2019 Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses ...
Julio C Ruiz +2 more
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ZFR coordinates crosstalk between RNA decay and transcription in innate immunity [PDF]
Nature Communications, 2018 Control of type I interferon production is crucial to combat infection while preventing deleterious inflammatory responses, but the extent of the contribution of post-transcriptional mechanisms to innate immune regulation is unclear.
Nazmul Haque +4 more
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An RNA decay factor wears a new coat: UPF3B modulates translation termination [version 1; referees: 3 approved] [PDF]
F1000Research, 2017 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that has been subject to intense scrutiny. NMD identifies and degrades subsets of normal RNAs, as well as abnormal mRNAs containing premature termination codons. A
Zhaofeng Gao, Miles Wilkinson
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ABCE1 Acts as a Positive Regulator of Exogenous RNA Decay [PDF]
Viruses, 2020 The 2′-5′-oligoadenylate synthetase (OAS)/RNase L system protects hosts against pathogenic viruses through cleavage of the exogenous single-stranded RNA.
Takuto Nogimori +7 more
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eLife, 2017 Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase.
Elizabeth V Wasmuth +4 more
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Surveillance-ready transcription: nuclear RNA decay as a default fate
Open Biology, 2018 Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which are subject to extensive processing. These processes are inherently error-prone, and cells have evolved robust quality control mechanisms to selectively remove ...
Stefan Bresson, David Tollervey
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Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells [PDF]
Frontiers in EndocrinologyIntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components.
Seyed M. Ghiasi +12 more
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