Cancer Research, 2021 This study has developed a novel NMD reporter system and identified a potential therapeutic approach of targeting the NMD pathway to treat cancer with spliceosome gene mutations.
Abigael Cheruiyot +18 more
semanticscholar +1 more source
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay. [PDF]
PLoS Genetics, 2013 Control of nuclear RNA stability is essential for proper gene expression, but the mechanisms governing RNA degradation in mammalian nuclei are poorly defined.
Stefan M Bresson, Nicholas K Conrad
doaj +1 more source
Extensive reshaping of bacterial operons by programmed mRNA decay. [PDF]
PLoS Genetics, 2018 Bacterial operons synchronize the expression of multiple genes by placing them under the control of a shared promoter. It was previously shown that polycistronic transcripts can undergo differential RNA decay, leaving some genes within the polycistron ...
Daniel Dar, Rotem Sorek
doaj +1 more source
Decay of enveloped SARS-CoV-2 and non-enveloped PMMoV RNA in raw sewage from university dormitories
Frontiers in Microbiology, 2023 IntroductionAlthough severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA has been frequently detected in sewage from many university dormitories to inform public health decisions during the COVID-19 pandemic, a clear understanding of SARS ...
Ye Li +19 more
doaj +1 more source
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
core +1 more source
Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response [PDF]
, 2014 Background Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels.
Costa, Maria J. (Maria João) +4 more
core +1 more source
Bio-Protocol, 2019 Cellular RNA levels are determined by the rates of RNA transcription from the gene template and subsequent RNA stability. Knowledge about both transcription and RNA decay is, therefore, necessary to interpret RNA levels and gene expression, especially ...
Manfred Schmid +2 more
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Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core +2 more sources
Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways
Viruses, 2016 To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from ...
Wendy Ullmer, Bert L. Semler
doaj +1 more source
The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm
Non-Coding RNA, 2022 Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated in the turnover of non ...
Luisa Kirchhof +8 more
doaj +1 more source