Results 91 to 100 of about 5,666,730 (325)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Messenger RNA regulation: to translate or to degrade [PDF]

The EMBO Journal, 2008
Quality control of gene expression operates post-transcriptionally at various levels in eukaryotes. Once transcribed, mRNAs associate with a host of proteins throughout their lifetime. These mRNA-protein complexes (mRNPs) undergo a series of remodeling events that are influenced by and/or influence the translation and mRNA decay machinery.
Ann-Bin, Shyu, Miles F, Wilkinson, Ambro, van Hoof   +2 more
openaire   +2 more sources

Regulation of heterochromatic RNA decay via heterochromatin protein 1 (HP1) [PDF]

, 2012
The central dogma of molecular biology describes the directional flow of biological information from DNA via RNA to protein. Information stored in DNA is copied to an mRNA molecule during the process of transcription.
Keller, Claudia Isabelle
core   +1 more source

Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli

Molecular Systems Biology, 2015
An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Huiyi Chen, Katsuyuki Shiroguchi, Hao Ge, Xiaoliang Sunney Xie   +3 more
doaj   +1 more source

5′ and 3′ modifications controlling RNA degradation: from safeguards to executioners

Philosophical Transactions of the Royal Society B: Biological Sciences, 2018
RNA degradation is a key process in the regulation of gene expression. In all organisms, RNA degradation participates in controlling coding and non-coding RNA levels in response to developmental and environmental cues. RNA degradation is also crucial for
D. Gagliardi, A. Dziembowski
semanticscholar   +1 more source

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

Nature Communications, 2022
LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited.
H. Hwang, Hongseok Ha, Banghyuk Lee, Bong Heon Kim, H. Song, Y. Kim   +5 more
semanticscholar   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Degradation of ribosomal RNA precursors by the exosome [PDF]

Nucleic Acids Research, 2000
The yeast exosome is a complex of 3'-->5' exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3' end processing of the 5.8S rRNA. Here we report that depletion of each of the individual components inhibits the early pre-rRNA cleavages at sites A(0), A(1), A(2)and A(3), reducing the levels ...
Allmang, Christine, Mitchell, Philip, Petfalski, Elisabeth, Tollervey, David   +3 more
openaire   +3 more sources

Protocol: high throughput silica-based purification of RNA from Arabidopsis seedlings in a 96-well format [PDF]

, 2011
The increasing popularity of systems-based approaches to plant research has resulted in a demand for high throughput (HTP) methods to be developed. RNA extraction from multiple samples in an experiment is a significant bottleneck in performing systems ...
Kane Steven, Kerr Lorraine E, Lorraine E Kerr, Salvo-Chirnside, Eliane, Kerr, Lorraine E, Steven Kane, Salvo-Chirnside Eliane, Kerr, Lorraine E., Kane, Steven, Eliane Salvo-Chirnside   +9 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source