Results 71 to 80 of about 5,666,730 (325)
RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Nature Communications, 2019 Cytosolic RNA degradation by the RNA exosome requires the Ski complex. Here the authors show that the proteins RST1 and RIPR assist the RNA exosome and the Ski complex in RNA degradation, thereby preventing the production of secondary siRNAs from ...
Heike Lange +15 more
doaj +1 more source
RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells
Bio-Protocol, 2017 The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Two degrading decades for RNA [PDF]
RNA, 2015 The last 20 years have seen an explosion of discoveries in the field of RNA research. Having obtained my PhD working on group II intron self-splicing, and given the mechanistic relationships between these introns and spliceosome-mediated splicing, I feel that one of the most remarkable achievements in the last two decades was the demonstration that RNA
openaire +4 more sources
Computational discovery of animal small RNA genes and targets [PDF]
, 2007 Though recently discovered, small RNAs appear to play a wealth of regulatory roles, being involved in degradation of target mRNAs, translation silencing of target genes, chromatin remodeling and transposon silencing.
Gaidatzis, Dimosthenis
core +1 more source
Axon micro-dissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons [PDF]
, 2020 Axonal protein synthesis has been shown to play a role in developmental and regenerative growth, as well as in the maintenance of the axoplasm in steady state.
Sotelo-Silveira, José Roberto +3 more
core +3 more sources
Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals. [PDF]
PLoS Genetics, 2015 Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and biochemical annotations of the signals required for
Jules Gagnon +4 more
doaj +1 more source
PLoS Pathogens, 2018 Wolbachia is currently being developed as a novel tool to block the transmission of dengue viruses (DENV) by Aedes aegypti. A number of mechanisms have been proposed to explain the DENV-blocking phenotype in mosquitoes, including competition for fatty ...
Saijo Thomas +3 more
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Complete probabilistic analysis of RNA shapes [PDF]
, 2006 Voß B, Giegerich R, Rehmsmeier M. Complete probabilistic analysis of RNA shapes. BMC Biology. 2006;4(1): 5.Background: Soon after the first algorithms for RNA folding became available, it was recognised that the prediction of only one energetically ...
Marc Rehmsmeier +8 more
core +1 more source