Results 51 to 60 of about 962,124 (298)

Small Molecule RNA Degraders

Angewandte Chemie
AbstractRNA is a central molecule in life, involved in a plethora of biological processes and playing a key role in many diseases. Targeting RNA emerges as a significant endeavor in drug discovery, diverging from conventional protein‐centric approaches to tackle various pathologies.
Javier Bonet‐Aleta, Tomoaki Maehara, Benjamin A. Craig, Gonçalo J. L. Bernardes   +3 more
openaire   +5 more sources

RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis

Nature Communications, 2019
Cytosolic RNA degradation by the RNA exosome requires the Ski complex. Here the authors show that the proteins RST1 and RIPR assist the RNA exosome and the Ski complex in RNA degradation, thereby preventing the production of secondary siRNAs from ...
Heike Lange, Simon Y. A. Ndecky, Carlos Gomez-Diaz, David Pflieger, Nicolas Butel, Julie Zumsteg, Lauriane Kuhn, Christina Piermaria, Johana Chicher, Michael Christie, Ezgi S. Karaaslan, Patricia L. M. Lang, Detlef Weigel, Hervé Vaucheret, Philippe Hammann, Dominique Gagliardi   +15 more
doaj   +1 more source

Impact of RNA degradation on gene expression profiling

BMC Medical Genomics, 2010
Background Gene expression profiling is a highly sensitive technique which is used for profiling tumor samples for medical prognosis. RNA quality and degradation influence the analysis results of gene expression profiles.
Opitz Lennart, Salinas-Riester Gabriela, Grade Marian, Jung Klaus, Jo Peter, Emons Georg, Ghadimi B Michael, Beißbarth Tim, Gaedcke Jochen   +8 more
doaj   +1 more source

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1 [PDF]

, 2015
Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease.
Amy L. Pashler, Benjamin P. Towler, Christopher I. Jones, Kannan, Sarah F. Newbury, Sophie R. Robinson   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals. [PDF]

PLoS Genetics, 2015
Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and biochemical annotations of the signals required for
Jules Gagnon, Mathieu Lavoie, Mathieu Catala, Francis Malenfant, Sherif Abou Elela   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells

Bio-Protocol, 2017
The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj   +1 more source

Investigating the mechanism behind the feedback regulation of the Exon Junction Complex component MAGOH [PDF]

, 2020
RNA binding proteins are critical for regulation of RNA function, and therefore maintaining appropriate levels of these proteins is important for cellular regulation.
Nega, Abigail
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source