Results 11 to 20 of about 509,868 (288)
Reticulocyte RNA-Dependent RNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1973 A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
K M, Downey +3 more
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Frontiers in Chemistry, 2022 Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome.
Guang-Feng Zhou +15 more
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SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study
Heliyon, 2020 The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad +4 more
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Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase
Frontiers in Immunology, 2022 GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral bioavailability of GS‐441524 poses a challenge to its anti-SARS-CoV-2 efficacy ...
Zhonglei Wang +3 more
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Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV. [PDF]
PLoS ONE, 2012 NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function interfering halts the virus infective cycle. This work aimed to produce cell penetrable humanized single domain antibodies (SdAb; VH/V(H)H) that interfere with the RdRp activity.
Kanyarat Thueng-in +7 more
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Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
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PLoS ONE, 2022 COVID-19 outbreak associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) raised health concerns across the globe and has been considered highly transmissible between people.
Ibrahim Khater, Aaya Nassar
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Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. [PDF]
PLoS ONE, 2014 Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp).
Romina Croci +10 more
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Inspection on the Mechanism of SARS-CoV-2 Inhibition by Penciclovir: A Molecular Dynamic Study
Molecules, 2022 In recent years, humanity has had to face a critical pandemic due to SARS-CoV-2. In the rapid search for effective drugs against this RNA-positive virus, the repurposing of already existing nucleotide/nucleoside analogs able to stop RNA replication by ...
Micaela Giannetti +3 more
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RNA-dependent RNA polymerase of tobacco plants [PDF]
Proceedings of the National Academy of Sciences, 1978 Several properties of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) active fractions obtained from tobacco plants, be they uninfected, infected with tobacco mosaic virus, or infected with tobacco necrosis virus, were compared.
M, Ikegami, H, Fraenkel-Conrat
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