Results 31 to 40 of about 4,371,568 (258)

In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR6

Bio-Protocol, 2018
RNA-dependent RNA polymerases (RdRPs) in eukaryotes convert single-stranded RNAs into double-stranded RNAs, thereby amplifying small interfering RNAs that play crucial roles in the regulation of development, maintenance of genome integrity and antiviral ...
Kyungmin Baeg, Yukihide Tomari, Hiro-oki Iwakawa   +2 more
doaj   +1 more source

Cytoplasmic RNA-dependent RNA-synthesis in maturing chicken erythrocytes. [PDF]

, 1976
Includes bibliographical references.An RNA-dependent RNA polymerase from ribosomes of maturing chicken erythrocytes was investigated. Concurrent with an increase in globin and RNA synthesis during phenylhydrazine induced anaemia, the total and specific ...
Boyd, Malcolm Charles David
core   +1 more source

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening

Frontiers in Genetics, 2020
BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao, Dan Han, Lei Sun, Yanhong Wu, Yanhong Wu, Shuang Liu, Shuang Liu, Yaojiang Huang, Yaojiang Huang   +8 more
doaj   +1 more source

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers. [PDF]

, 2014
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon)
Forrest, S, Lear, Z, Ryan, M., Herod, M, Forrest, S., Ryan, M, Stonehouse, N.J., Rowlands, DJ, Herod, M.R., Stonehouse, NJ, Lear, Z., Rowlands, D.J., Ryan, M.; id_orcid   +12 more
core   +1 more source

Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea. [PDF]

, 2009
Contains fulltext : 80405.pdf (Publisher’s version ) (Open Access)One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the ...
Makarova, K.S., Siebers Bettina, Koonin Eugene V, Bettina Siebers, Siebers, B.G., Kira S Makarova, Blombach Fabian, Fabian Blombach, Makarova Kira S, John Oost, Koonin, E.V., Oost, J., van der, Siebers, B., Marrero, J., Oost John, Blombach, F., Oost, J. van der, Marrero Jeannette, Jeannette Marrero, Eugene V Koonin   +19 more
core   +1 more source

Conformational analysis between 6M71 (SARS COV2 RNA-dependent RNA polymerase) and CHEMBL3120791 using GROMACS Molecular Dynamic simulation. [PDF]

, 2021
We analyzed molecular dynamic simulation using GROMACS to study the interaction between SARS-Cov-2 cryo-EM structure of RNA-dependent RNA polymerase (PDB ID: 6M71) and compound CHEMBL3120791 with 20ns simulation using NVIDIA GPU for high performance ...
Pavan, Gudipati
core   +1 more source

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Nature Communications, 2017
The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva   +6 more
doaj   +1 more source

Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes

Molecules, 2021
The work is devoted to the study of the complementarity of the electronic structures of the ligands and SARS-CoV-2 RNA-dependent RNA polymerase. The research methodology was based on determining of 3D maps of electron densities of complexes using an ...
Nadezhda Palko, Maria Grishina, Vladimir Potemkin   +2 more
doaj   +1 more source

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages [PDF]

, 2015
Date of Acceptance: 02/01/2015Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Jones, John T., Murray E Selkirk, John T Jones, Goldstein, R, Phillip M. Schiffer (691095), Bob Goldstein, Miska, E A, Taylor, Mark J., Eric A. Miska (41828), Blaxter, Mark L., Murray E. Selkirk (202480), Miska, Eric A., Christopher Kraus (691096), John T. Jones (207247), Fast, Naomi M., Sarkies, P, Peter Sarkies (691090), Alex Ardila-Garcia, Ben Hanelt (107535), Blok, V, Schiffer, Phillip M., Georgios Koutsovoulos (556628), Hanelt, Ben, Georgios Koutsovoulos, Boothby, Thomas, Ben Hanelt, Naomi M. Fast (691094), Koutsovoulos, Georgios, Mark J Taylor, Bob Goldstein (265221), Selkirk, Murray E., Phillip M Schiffer, Ardila-Garcia, Alex, Eric A Miska, Alex Ardila-Garcia (691093), Thomas Boothby, Hanelt, B, Mark J. Taylor (118298), Thomas Boothby (691092), Mark L. Blaxter (115482), Selkirk, M E, Vivian Blok (691091), Blok, Vivian, Naomi M Fast, Taylor, Mark; id_orcid, Kraus, C, Schiffer, P M, Sarkies, Peter, Jones, J T, Goldstein, Bob, Fast, N M, Christopher Kraus, Koutsovoulos, G, Taylor, M J, Ardila-Garcia, A, Mark L Blaxter, Kraus, Christopher, Blaxter, M L, Boothby, T, Peter Sarkies, Vivian Blok   +60 more
core   +2 more sources

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

Viruses, 2010
More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill, Matthias Götte, Jean A. Bernatchez   +2 more
doaj   +1 more source