Results 11 to 20 of about 4,371,568 (258)

Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase [PDF]

Scientific Reports
Human noroviruses (HuNoVs) are the leading cause of non-bacterial gastroenteritis worldwide, exhibiting extensive genetic diversity driven by recombination and mutation.
Annika Flint, Maryam Jawad, Neda Nasheri
doaj   +2 more sources

Structural and functional characterisation of the Crimean-Congo haemorrhagic fever virus RNA dependent RNA polymerase [PDF]

Nature Communications
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is found across Africa, Asia, and the Middle East where it can cause Haemorrhagic outbreaks with high case fatality rates.
Adrian Deng, Rory Cunnison, Loïc Carrique, Franziska Günl, Els Pardon, Jan Steyaert, David Nguyen Duc, Jonathan M. Grimes, Nicole Robb, Jeremy R. Keown   +9 more
doaj   +3 more sources

Structures of the Crimean-Congo hemorrhagic fever virus RNA-dependent RNA polymerase [PDF]

Cell Discovery
Crimean-Congo hemorrhagic fever virus (CCHFV), designated by the WHO as a priority pathogen under its R&D Blueprint for emerging epidemics, poses a major global health threat, yet licensed vaccines or specific antiviral treatments are lacking.
Mengyun Li, Kaixiang Zhu, Yanan Liu, Kun Shang, Yuanhao Li, Xinyue Wang, Jianing Wang, Jie Jia, Xin Ai, Dongcun Ni, Sheng Cui, Hongtao Zhu, Xiaopan Gao   +12 more
doaj   +2 more sources

Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8 [PDF]

Scientific Reports
The replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand.
Merlyn Latimer-Smith, Paula S. Salgado, Ismay Forsyth, Eugene Makeyev, Minna M. Poranen, Dave I. Stuart, Jonathan M. Grimes, Kamel El Omari   +7 more
doaj   +2 more sources

Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase [PDF]

Heliyon
The SARS-CoV-2 pandemic caused millions of deaths due to its prominent infectivity and mortality. Although the vaccines and medicines for SARS-CoV-2 are on the market, new coronavirus variants like influenza are expected to reemerge continuously ...
Kyoung Won Youn, Siyun Lee, Jang Hoon Kim, Yea-In Park, Jaeyeon So, Chansoo Kim, Chong Woon Cho, Junsoo Park   +7 more
doaj   +2 more sources

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]

, 2012
tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena, Turowski, Tomasz W., Karkusiewicz, Iwona, Kowal, J   +3 more
core   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin, Martin G, Keller W   +5 more
core   +1 more source