Results 41 to 50 of about 4,371,568 (258)

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Identifying Therapeutic Compounds Targeting RNA-Dependent-RNA-Polymerase of Sars-Cov-2 [PDF]

, 2020
COVID-19 emerged as the biggest threat of this century for mankind and later it spread across the globe through human to human transmission. Scientists rushed to understand the structure and mechanism of the virus so that antiviral drugs or vaccines to ...
Muhammad, Roomi, Yaser, Khan, Muhammad, Mahmood   +2 more
core   +1 more source

Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]

, 2007
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David, Dlakic, Mensur, Dez, Christophe   +2 more
core   +1 more source

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

Virology Journal, 2007
Background Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases.
Vaccaro Joseph A, Freistadt Marion S, Eberle Karen E   +2 more
doaj   +1 more source

Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]

, 2008
Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Frontiers in Microbiology, 2022
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein.
Kittirat Glab-ampai, Kanasap Kaewchim, Kanasap Kaewchim, Techit Thavorasak, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra   +12 more
doaj   +1 more source

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers, Henderson Charlotte A., Mardle Charlotte E., Callaghan Anastasia J., Pickford Andrew R., Phillips Jack O., Butt Louise E., Gowers Darren M., Vincent Helen A., Roberts Adam J., Stone Carlanne M.   +39 more
core   +2 more sources

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. [PDF]

, 2011
RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts in Pol II and Pol III complexes, are functionally conserved using heterospecific ...
Gadal, O., Leger-Silvestre, Isabelle, Ostermaier, M.K., Panov, Konstantin; id_orcid, Panov, Kostya I, Schultz, P., Leger-Silvestre, I. (I), Olivier Gadal, Jorge Pérez-Fernández, Albert, Benjamin, Leger-Silvestre, I., Ostermaier, Martin K, Kostya I. Panov, Perez-Fernandez, J., Normand, C. (C), Schultz, Patrick, Schultz, P. (Patrick), Panov, Kostya I., Patrick Schultz, Gadal, O. (O), Normand, Christophe, Martin K. Ostermaier, Normand, C., Zomerdijk, Joost C.B.M., Albert, B. (B), Perez-Fernandez, J. (J), Ostermaier, M. (M) K. (K), Ostermaier, Martin K., Christophe Normand, Zomerdijk, Joost C B M, Gadal, Olivier, Joost C.B.M. Zomerdijk, Zomerdijk, J.C., Perez-Fernandez, Jorge, Isabelle Léger-Silvestre, Albert, B., Panov, K. (K) I. (I), Zomerdijk, Joost C. B. M., Benjamin Albert, Zomerdijk, J. (J) C. (C)   +39 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source