Results 91 to 100 of about 2,110,017 (419)

RNA editing: Rewriting receptors [PDF]

Current Biology, 1997
The type of RNA editing that converts adenosine to inosine in double-stranded RNA generates different isoforms of subunits of the ionotropic glutamate-gated ion channel receptors. Recently, it has been reported that the pre-mRNA of the serotonin 2C receptor can be edited by the same mechanism.
openaire   +3 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Genome-wide profiling of RNA editing sites in sheep

Journal of Animal Science and Biotechnology, 2019
Background The widely observed RNA-DNA differences (RDDs) have been found to be due to nucleotide alteration by RNA editing. Canonical RNA editing (i.e., A-to-I and C-to-U editing) mediated by the adenosine deaminases acting on RNA (ADAR) family and ...
Yuanyuan Zhang, Deping Han, Xianggui Dong, Jiankui Wang, Jianfei Chen, Yanzhu Yao, Hesham Y. A. Darwish, Wansheng Liu, Xuemei Deng   +8 more
doaj   +1 more source

Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer

Frontiers in Oncology, 2020
A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and ...
Chi Zhou, Zhiting Wei, Liye Zhang, Zhaoyi Yang, Qi Liu   +4 more
doaj   +1 more source

RNA editing affects cis‐regulatory elements and predicts adverse cancer survival

Cancer Medicine, 2021
Background RNA editing exerts critical impacts on numerous biological processes and thus are implicated in crucial human phenotypes, including tumorigenesis and prognosis.
Yuan‐Ming Wu, Yan Guo, Hui Yu, Tao Guo
doaj   +1 more source

ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs [PDF]

, 2005
Posttranscriptional, site-specific adenosine to inosine (A-to-I) base conversions, designated as RNA editing, play significant roles in generating diversity of gene expression.
Basyuk, Eugenia, Bertrand, Edouard, Cavaillé, Jérôme, Huttenhofer, Alexander, Le Meur, Elodie, Muscatelli, Françoise, Vitali, Patrice   +6 more
core   +8 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Nature Communications
The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter protein ...
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou   +9 more
doaj   +1 more source

Genome-wide characterization of RNA editing highlights roles of high editing events of glutamatergic synapse during mouse retinal development

Computational and Structural Biotechnology Journal, 2022
Adenosine-to-inosine (A-to-I) RNA editing leads to functional change of neurotransmitter receptor which is essential for neurotransmission and normal neuronal development. As a highly accessible part of central nervous system, retina has been extensively
Chenghao Li, Xinrui Shi, Jiaying Yang, Ke Li, Lijun Dai, Yan Zhang, Meng Zhou, Jianzhong Su   +7 more
doaj  

Template-based eukaryotic genome editing directed by SviCas3 [PDF]

arXiv, 2023
RNA-guided gene editing based on the CRISPR-Cas system is currently the most effective genome editing technique. Here, we report that the SviCas3 from the subtype I-B-Svi Cas system in Streptomyces virginiae IBL14 is an RNA-guided and DNA-guided DNA endonuclease suitable for the HDR-directed gene and/or base editing of eukaryotic cell genomes.
arxiv