Results 81 to 90 of about 1,495,760 (258)

Profiling RNA Editing in Single Cells

, 2023
: RNA editing is a widespread molecular phenomenon occurring in a variety of organisms. In humans, it mainly involves the deamination of adenosine to inosine (A-to-I) in double-stranded RNAs by ADAR enzymes.
Pesole, Graziano, Fonzino, Adriano, Picardi, Ernesto   +2 more
core   +1 more source

C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

Scientific Reports
Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez, Franz Josef Gassner, Dominik Baumgartner, Philine Hoven, Ekaterina Akimova, Markus Steiner, Stephanie Schlichtner, Stefanie Rauscher, Ferran Nadeu, Elias Campo, Richard Greil, Alexander Egle, Lisa Pleyer, Nadja Zaborsky, Roland Geisberger   +14 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]

, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Westhof, E. (Eric), Mattick, John S., Mattick, J. (J) S. (S), Cattenoz, P. (P) B. (B), Taft, R. (R) J. (J), Cattenoz, Pierre B., Taft, Ryan J., Westhof, Eric   +7 more
core   +1 more source

Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure.

PLoS Pathogens, 2013
Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This
Masfique Mehedi, Thomas Hoenen, Shelly Robertson, Stacy Ricklefs, Michael A Dolan, Travis Taylor, Darryl Falzarano, Hideki Ebihara, Stephen F Porcella, Heinz Feldmann   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Site-selective versus promiscuous A-to-I editing

, 2011
RNA editing by adenosine deamination is acting on polymerase II derived transcripts in all metazoans. Adenosine-to-inosine (A-to-I) editing is mediated by the adenosine deaminase that acts on RNA (ADAR) enzymes. Two types of adenosine to inosine (A-to-I)
Öhman, Marie,, Wahlstedt, Helene,, Helene Wahlstedt, Marie fxhman   +3 more
core   +1 more source

Genome-Wide Tissue-Specific RNA Editability Estimation Through Convolution Neural Networks

Tsinghua Science and Technology
RiboNucleic Acid (RNA) editing is a dynamic and essential biological process that has multifaceted functions in gene regulation, protein diversity, and immune response.
Yan Guo, Jiandong Wang, Fengyao Yan, Jijun Tang, Fei Guo, Limin Jiang   +5 more
doaj   +1 more source

Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro, Emily C. Freund, Lucas Restrepo, Huan-Huan Qiao, Amruta Bhate, Qin Li, Jian-Quan Ni, Timothy J. Mosca, Jin Billy Li   +8 more
doaj   +1 more source