Results 121 to 130 of about 559,966 (299)

RNA editing in nascent RNA affects pre-mRNA splicing [PDF]

, 2018
In eukaryotes, nascent RNA transcripts undergo an intricate series of RNA processing steps to achieve mRNA maturation. RNA editing and alternative splicing are two major RNA processing steps that can introduce significant modifications to the final gene ...
Giovanni Quinones-Valdez, Ei-Wen Yang, Lin, Xianzhi, Jae Hoon Bahn, Hsiao, Yun-Hua Esther, Xiao, Xinshu, Yun Yang, Bahn, Jae Hoon, Yang, Yun, Yang, Ei-Wen, Stephen Tran, Tran, Stephen, Quinones-Valdez, Giovanni, Xinshu Xiao, Xianzhi Lin, Yun-Hua Esther Hsiao   +15 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Stewart, B.J., Carnegie, P., Pain, G.N., Dawkins, R.L., Steele, E.J., Williamson, J.F., Lindley, R.A., Millman, J.A., Lester, S.   +8 more
core  

RNA editing and autophagy in Drosophila melanogaster [PDF]

, 2012
Post-transcriptional regulation of gene expression involves a diverse set of mechanisms such as RNA splicing, RNA localization, and RNA turn-over. Adenosine to Inosine (A-to-I) RNA editing is an additional post-transcriptional regulatory mechanism ...
Paro, Simona
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Arabidopsis thaliana RNA Editing Factor SLO2, which affects the mitochondrial electron transport chain, participates in multiple stress and hormone responses

, 2014
Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrial electron transport, and vital for plant growth through regulation of carbon and energy metabolism.
Dugardeyn, J., Peter J. Eastmond, Cammue, Bruno, Qiang Zhu, Roland Valcke, Barbara De Coninck, De Coninck, B., Prinsen, Els, Jasper Dugardeyn, Dominique Van Der Straeten, Dugardeyn, Jasper, Mühlenbock, Per, Van Der Straeten, Dominique, Eastmond, P.J., Zhang, Chunyi, Prinsen, E., Öden, Sevgi, Karampelias, M., Bruno P.A. Cammue, Cammue, B. P. A., Els Prinsen, Eastmond, P. J., Michael Karampelias, De Coninck, Barbara, Eastmond, Peter J., Chunyi Zhang, Per Mühlenbock, Oden, S., Eastmond, Peter J, Karampelias, Michail, Valcke, Roland, Karampelias, Michael, Cammue, Bruno PA, Valcke, R., Zhang, C., Muhlenbock, P., Zhu, Q., Zhu, Qiang, Van Der Straeten, D., Cammue, Bruno P. A., Sevgi Öden   +40 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A-to-I Editing Is Subtype-Specific in Non-Hodgkin Lymphomas

Cancer is a complex and heterogeneous disease, in which a number of genetic and epigenetic changes occur in tumor onset and progression. Recent studies indicate that changes at the RNA level are also involved in tumorigenesis, such as adenosine-to ...
Cai Chen, Ralf Bundschuh
core   +1 more source