Results 131 to 140 of about 2,110,017 (419)
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Comparing RNA structures using a full set of biologically relevant edit operations is intractable [PDF]
arXiv, 2008 Arc-annotated sequences are useful for representing structural information of RNAs and have been extensively used for comparing RNA structures in both terms of sequence and structural similarities. Among the many paradigms referring to arc-annotated sequences and RNA structures comparison (see \cite{IGMA_BliDenDul08} for more details), the most ...
arxiv
dbRES: a web-oriented database for annotated RNA editing sites [PDF]
, 2006 Although a large amount of experimentally derived information about RNA editing sites currently exists, this information has remained scattered in a variety of sources and in diverse data formats.
Du, Pufeng, He, Tao, Li, Yanda
core +2 more sources
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Interfering with interferon by RNA editing [PDF]
Nature Reviews Molecular Cell Biology, 2018 By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells.
openaire +2 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
GUN1 interacts with MORF2 to regulate plastid RNA editing during retrograde signaling
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Retrograde signaling and posttranscriptional RNA editing are important regulatory processes for chloroplast development and function in flowering plants. GUN1 is a central integrator of chloroplast retrograde signaling pathways.
Xiaobo Zhao, Jianyan Huang, J. Chory
semanticscholar +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Evolving Boolean Networks with RNA Editing [PDF]
arXiv, 2015 The editing of transcribed RNA by other molecules such that the form of the final product differs from that specified in the corresponding DNA sequence is ubiquitous. This paper uses an abstract, tunable Boolean genetic regulatory network model to explore aspects of RNA editing.
arxiv
Regulation of RNA editing by RNA-binding proteins in human cells
Communications Biology, 2019 Adenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate
Giovanni Quinones-Valdez +12 more
semanticscholar +1 more source