Results 171 to 180 of about 2,110,017 (419)
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]
, 2019 We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao +7 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
RNA Editing Intermediates of cox2 Transcripts in Maize Mitochondria [PDF]
, 1991 Austin J. Yang, R. Michael Mulligan
openalex +1 more source
Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages [PDF]
, 2014 RNA editing refers to the process by which the sequence of RNA is altered through the insertion, deletion or modification of specific nucleotides. Editing of mRNA transcripts can increase the informational complexity encoded by the genome by producing ...
Hamilton, Claire Ellen
core +2 more sources
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
RNA editing by G-nucleotide insertion in mumps virus P-gene mRNA transcripts [PDF]
, 1990 Reay G. Paterson, Robert A. Lamb
openalex +1 more source
BMC Bioinformatics, 2018 Gene expression in plant chloroplasts and mitochondria is affected by RNA editing. Numerous C-to-U conversions, accompanied by reverse U-to-C exchanges in some plant clades, alter the genetic information encoded in the organelle genomes.
Henning Lenz +2 more
semanticscholar +1 more source
Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro [PDF]
, 2020 Adenosine deaminases acting on RNA (ADARs) convert adenosine-to-inosine in double stranded RNA. Selectivity of editing sites depends on the sequence of the RNA as well as the secondary structure.
Bartley, Mariel Therese
core +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers
Tumor Biology, 2017 RNA editing is a widespread post-transcriptional mechanism that confers specific and reproducible nucleotide changes in selected RNA transcripts and plays a critical role in many human cancers.
Xueda Hu +11 more
doaj +1 more source