Results 281 to 290 of about 2,110,017 (419)

Enhancing RNA editing efficiency and specificity with engineered ADAR2 guide RNAs. [PDF]

Mol Ther Nucleic Acids
Ai X, Ding S, Zhou S, Du F, Liu S, Cui X, Dong J, Huang X, Tang Z.   +8 more
europepmc   +1 more source

Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation

Advanced Healthcare Materials, EarlyView.
This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth, Zachary S.C.S. Froom, Natasha D. Osborne, Christian N. Rempe, Brenden Wheeler, Kyle Medd, Neal I. Callaghan, Huikang Qian, Abhinav P. Acharya, Carlie Charron, Locke Davenport Huyer   +10 more
wiley   +1 more source

A single alteration 20 nt 5' to an editing target inhibits chloroplast RNA editing in vivo [PDF]

, 2001
Martha L. Reed
openalex   +1 more source

BIRC3 RNA Editing Modulates Lipopolysaccharide-Induced Liver Inflammation: Potential Implications for Animal Health. [PDF]

Int J Mol Sci
Li W, Cao D, Shi M, Yang X.
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Mitochondrial genome of Lonicera macranthoides: features, RNA editing, and insights into male sterility. [PDF]

Front Plant Sci
Chen Z, Zhuo W, Wang Y, Qi J, Liu L, Lu S, Wang H, Sun T, Wang L, Ren F.   +9 more
europepmc   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

CRISPR-Cas13-mediated RNA editing in the silkworm Bombyx mori. [PDF]

Zool Res
Tang YH, Zhang X, Dai ZC, Li H, Yang Y, Zhao TJ, Yuan DQ, Qian WL, Cheng DJ.   +8 more
europepmc   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

The specificity of nucleotide removal during RNA editing in Trypanosoma brucei [PDF]

, 2001
Sobomabo D. Lawson, Robert P. Igo, Reza Salavati, Kenneth Stuart   +3 more
openalex   +1 more source