The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
doaj +1 more source
Combining Insertion and Deletion in RNA-editing Preserves Regularity [PDF]
, 2012 Inspired by RNA-editing as occurs in transcriptional processes in the living cell, we introduce an abstract notion of string adjustment, called guided rewriting. This formalism allows simultaneously inserting and deleting elements.
Bošnački, D. +2 more
core +3 more sources
RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
core +2 more sources
Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver [PDF]
, 2014 BackgroundRNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of
Billing, Anja M +11 more
core +3 more sources
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS
Frontiers in Endocrinology, 2023 BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong +19 more
doaj +1 more source
RDDpred: a condition-specific RNA-editing prediction model from RNA-seq data [PDF]
, 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Benjamin Hur, Min-su Kim, Sun Kim
core +2 more sources
Cellular and genetic drivers of RNA editing variation in the human brain
Nature Communications, 2022 Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly described.
Winston H. Dredge +8 more
doaj +1 more source
Genome-wide identification of A-to-I RNA editing events provides the functional implications in PDAC
Frontiers in Oncology, 2023 IntroductionRNA editing, a wide-acknowledged post-transcriptional mechanism, has been reported to be involved in the occurrence and development of cancer, especially the abnormal alteration of adenosine to inosine.
Yue Mei +11 more
doaj +1 more source
The contribution of Alu exons to the human proteome. [PDF]
, 2016 BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng +7 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source