Results 41 to 50 of about 2,133,969 (419)
Frontiers in Oncology, 2020 RNA editing is a widespread post-transcriptional mechanism to introduce single nucleotide changes to RNA in human cancers. Here, we characterized the global RNA editing profiles of 373 hepatocellular carcinoma (HCC) and 50 adjacent normal liver samples ...
Juan Chen +5 more
doaj +1 more source
RNA Editing in Chloroplasts of Spirodela polyrhiza, an Aquatic Monocotelydonous Species. [PDF]
PLoS ONE, 2015 RNA editing is the post-transcriptional conversion from C to U before translation, providing a unique feature in the regulation of gene expression.
Wenqin Wang +4 more
doaj +1 more source
On the origin and evolution of RNA editing in metazoans [PDF]
Cell Reports, 2020 AbstractExtensive adenosine-to-inosine (A-to-I) editing of nuclear-transcribed RNAs is the hallmark of metazoan transcriptional regulation, and is fundamental to numerous biochemical processes. Here we explore the origin and evolution of this regulatory innovation, by quantifying its prevalence in 22 species that represent all major transitions in ...
Qunfei Guo +20 more
openaire +7 more sources
Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. [PDF]
PLoS ONE, 2012 RNA editing is a process that modifies RNA nucleotides and changes the efficiency and fidelity of the central dogma. Enzymes that catalyze RNA editing are required for life, and defects in RNA editing are associated with many diseases. Recent advances in
Tongjun Gu +5 more
doaj +1 more source
Is abundant A-to-I RNA editing primate-specific? [PDF]
Trends in Genetics, Vol. 21, 77-81 (2005), 2004 A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly.
arxiv +1 more source
Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]
, 2019 Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven +10 more
core +1 more source
RNA editing of human microRNAs [PDF]
Genome Biology, 2006 Abstract Background MicroRNAs (miRNAs) are short RNAs of around 22 nucleotides that regulate gene expression. The primary transcripts of miRNAs contain double-stranded RNA and are therefore potential substrates for adenosine to inosine (A-to-I) RNA editing ...
Blow, Matthew J +7 more
openaire +4 more sources
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
doaj +1 more source
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
, 2012 Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor +58 more
core +1 more source
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Nature Communications, 2021 Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I ...
Sonia Jimeno +16 more
doaj +1 more source