Results 21 to 30 of about 559,966 (299)

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source

BreenMS/Developmental-RNA-editing: Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development

, 2022
Code used to process the following manuscript: Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites remains challenging.
Michael S. Breen, PhD
core   +1 more source

Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing. [PDF]

PLoS Genetics, 2013
In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product.
Stéphane Bentolila, Julyun Oh, Maureen R Hanson, Robert Bukowski   +3 more
doaj   +1 more source

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
core   +1 more source

E-I balance and human diseases - from molecules to networking

Frontiers in Molecular Neuroscience, 2008
Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development.
Sabrina A Eichler, Jochen C Meier
doaj   +1 more source

The landscape of coding RNA editing events in pediatric cancer

BMC Cancer, 2021
Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen, Michael Rusch, Samuel W. Brady, Ying Shao, Michael N. Edmonson, Timothy I. Shaw, Brent B. Powers, Liqing Tian, John Easton, Charles G. Mullighan, Tanja Gruber, David Ellison, Jinghui Zhang   +12 more
doaj   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie, Schnaufer, Achim; id_orcid, Stuart, Kenneth, Carnes, Jason, Lerch, Melissa, Guo, Xuemin   +5 more
core   +1 more source

C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code

, 2022
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which ...
Sonali Bhakta, Toshifumi Tsukahara, Tsukahara, Toshifumi, Bhakta, Sonali   +3 more
core   +1 more source

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo
Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli, Angela Gallo   +9 more
doaj   +1 more source

RNA Editing: An I for editing [PDF]

Current Biology, 1995
In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
openaire   +2 more sources