Results 21 to 30 of about 1,495,760 (258)

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie, Schnaufer, Achim; id_orcid, Stuart, Kenneth, Carnes, Jason, Lerch, Melissa, Guo, Xuemin   +5 more
core   +1 more source

BreenMS/Developmental-RNA-editing: Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development

, 2022
Code used to process the following manuscript: Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites remains challenging.
Michael S. Breen, PhD
core   +1 more source

E-I balance and human diseases - from molecules to networking

Frontiers in Molecular Neuroscience, 2008
Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development.
Sabrina A Eichler, Jochen C Meier
doaj   +1 more source

The landscape of coding RNA editing events in pediatric cancer

BMC Cancer, 2021
Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen, Michael Rusch, Samuel W. Brady, Ying Shao, Michael N. Edmonson, Timothy I. Shaw, Brent B. Powers, Liqing Tian, John Easton, Charles G. Mullighan, Tanja Gruber, David Ellison, Jinghui Zhang   +12 more
doaj   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin   +3 more
core   +1 more source

C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code

, 2022
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which ...
Sonali Bhakta, Toshifumi Tsukahara, Tsukahara, Toshifumi, Bhakta, Sonali   +3 more
core   +1 more source

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo
Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli, Angela Gallo   +9 more
doaj   +1 more source

Glycine receptors caught between genome and proteome - functional implications of RNA editing and splicing

Frontiers in Molecular Neuroscience, 2009
Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged ...
Pascal Legendre, Pascal Legendre, Pascal Legendre, Benjamin Förstera, Benjamin Förstera, Rene Jüttner, Jochen C Meier   +6 more
doaj   +1 more source

Developing Collaborative XML Editing Systems [PDF]

, 2007
In many areas the eXtensible Mark-up Language (XML) is becoming the standard exchange and data format. More and more applications not only support XML as an exchange format but also use it as their data model or default file format for graphic, text and ...
Gerlicher, Ansgar Robert Sandy
core   +5 more sources

Genome-Wide Analysis on Driver and Passenger RNA Editing Sites Suggests an Underestimation of Adaptive Signals in Insects

, 2023
Adenosine-to-inosine (A-to-I) RNA editing leads to a similar effect to A-to-G mutations. RNA editing provides a temporo-spatial flexibility for organisms.
Yuchen Zhang, Yuange Duan
core   +1 more source