Results 11 to 20 of about 559,966 (299)
RNA editing in kinetoplastids [PDF]
RNA Biology, 2010 RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited mRNA and in most cases a trans-acting guide RNA (gRNA). Sequences within gRNAs define the position and extend of mRNA editing.
Hajduk, Stephen, Ochsenreiter, Torsten
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RNA editing in cardiovascular health and disease [PDF]
Communications BiologyPost-transcriptional RNA modifications can alter RNA structure, stability, localization, and function. Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that converts adenosine nucleotides in RNA to inosine nucleotides ...
Xiaoxin Huang +3 more
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FEMS Microbiology Reviews, 1999 The term RNA editing describes those molecular processes in which the information content is altered in an RNA molecule. To date such changes have been observed in tRNA. rRNA and mRNA molecules of eukaryotes, but not prokaryotes. The demonstration of RNA editing in prokaryotes may only be a matter of time, considering the range of species in which the ...
A, Brennicke, A, Marchfelder, S, Binder
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N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N 1 ...
Tien-Hao Chen +4 more
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RNA editing regulates lncRNA splicing in human early embryo development.
PLoS Computational Biology, 2021 RNA editing is a co- or post-transcriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription.
Jiajun Qiu +3 more
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Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma
Molecules, 2020 Glioblastoma (GBM) is the most aggressive, infiltrative, and lethal brain tumor in humans. Despite the extensive advancement in the knowledge about tumor progression and treatment over the last few years, the prognosis of GBM is still very poor due to ...
Valeriana Cesarini +6 more
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Forestry Research, 2021 RNA-editing is a post-transcriptional modification that can diversify genome-encoded information by modifying individual RNA bases. In contrast to the well-studied RNA-editing in organelles, little is known about nuclear RNA-editing in higher plants.
Yiran Wang +3 more
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RNA Biology, 2010 In plants, post-transcriptional modification of transcripts includes C-to-U, U-to-C and A-to-I editing. RNA editing in plants is essential, with many mutants impaired in editing of specific sites exhibiting strong deleterious phenotypes, even lethality.
Chateigner-Boutin, Anne Laure +1 more
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An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
, 2007 RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
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Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
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