Results 11 to 20 of about 702,073 (296)

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source

The landscape of coding RNA editing events in pediatric cancer

BMC Cancer, 2021
Background RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.
Ji Wen, Michael Rusch, Samuel W. Brady, Ying Shao, Michael N. Edmonson, Timothy I. Shaw, Brent B. Powers, Liqing Tian, John Easton, Charles G. Mullighan, Tanja Gruber, David Ellison, Jinghui Zhang   +12 more
doaj   +1 more source

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]

, 2012
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik, Altschul, Andrew C. Penn, Arzumanov, Arzumanov, Balik, Bass, Birney, Brusa, Carver, Daniel, Darty, Dominski, Egebjerg, Eisen, Enstero, Feldmeyer, Gallo, Ge, Greger, Hamada, Heasman, Higuchi, Higuchi, Hogg, Ingo H. Greger, Jepson, Jubin, Katoh, Kent, Kwak, Laurencikiene, Maas, Moulton, Peng, Reenan, Rice, Rosenthal, Rueter, Ryman, Schoft, Sommer, Stephens, Summerton, Summerton, Summerton, Tariq, Traynelis, Valente, Venkatesh, Yamashita, Yang   +51 more
core   +1 more source

E-I balance and human diseases - from molecules to networking

Frontiers in Molecular Neuroscience, 2008
Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development.
Sabrina A Eichler, Jochen C Meier
doaj   +1 more source

Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing. [PDF]

PLoS Genetics, 2013
In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product.
Stéphane Bentolila, Julyun Oh, Maureen R Hanson, Robert Bukowski   +3 more
doaj   +1 more source

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo
Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli, Angela Gallo   +9 more
doaj   +1 more source

Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]

, 2019
Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven, Blanchette, Robert A, Cullen, Daniel, Gaskell, Jill, Grigoriev, Igor V, Hibbett, David S, Master, Emma, Schilling, Jonathan S, Toapanta, Christina, Wu, Baojun, Zhang, Jiwei   +10 more
core   +1 more source

Glycine receptors caught between genome and proteome - functional implications of RNA editing and splicing

Frontiers in Molecular Neuroscience, 2009
Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged ...
Pascal Legendre, Pascal Legendre, Pascal Legendre, Benjamin Förstera, Benjamin Förstera, Rene Jüttner, Jochen C Meier   +6 more
doaj   +1 more source

Genomic Identification of RNA Editing Through Integrating Omics Datasets and the Clinical Relevance in Hepatocellular Carcinoma

Frontiers in Oncology, 2020
RNA editing is a widespread post-transcriptional mechanism to introduce single nucleotide changes to RNA in human cancers. Here, we characterized the global RNA editing profiles of 373 hepatocellular carcinoma (HCC) and 50 adjacent normal liver samples ...
Juan Chen, Lu Wang, Fangbin Wang, Jian Liu, Jian Liu, Zhenyu Bai   +5 more
doaj   +1 more source

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

Nature Communications, 2021
Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I ...
Sonia Jimeno, Rosario Prados-Carvajal, María Jesús Fernández-Ávila, Sonia Silva, Domenico Alessandro Silvestris, Martín Endara-Coll, Guillermo Rodríguez-Real, Judit Domingo-Prim, Fernando Mejías-Navarro, Amador Romero-Franco, Silvia Jimeno-González, Sonia Barroso, Valeriana Cesarini, Andrés Aguilera, Angela Gallo, Neus Visa, Pablo Huertas   +16 more
doaj   +1 more source