Genomic Positional Dissection of RNA Editomes in Tumor and Normal Samples
Frontiers in Genetics, 2019 RNA editing is phenomenon that occurs in both protein coding and non-coding RNAs. Increasing evidence have shown that adenosine-to-inosine RNA editing can potentially rendering substantial functional effects throughout the genome.
Michael Chigaev +8 more
doaj +1 more source
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
doaj +1 more source
RNA Editing in Chloroplasts of Spirodela polyrhiza, an Aquatic Monocotelydonous Species. [PDF]
PLoS ONE, 2015 RNA editing is the post-transcriptional conversion from C to U before translation, providing a unique feature in the regulation of gene expression.
Wenqin Wang +4 more
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The Role of RNA Editing in Cancer Development and Metabolic Disorders
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
doaj +1 more source
RNA Editing and Its Roles in Plant Organelles
Frontiers in Genetics, 2021 RNA editing, a vital supplement to the central dogma, yields genetic information on RNA products that are different from their DNA templates. The conversion of C-to-U in mitochondria and plastids is the main kind of RNA editing in plants. Various factors
Wei Hao +12 more
doaj +1 more source
RNA Editing and Drug Discovery for Cancer Therapy
The Scientific World Journal, 2013 RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers.
Wei-Hsuan Huang +5 more
doaj +1 more source
Population and allelic variation of A-to-I RNA editing in human transcriptomes
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
doaj +1 more source
The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
doaj +1 more source
Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene. [PDF]
, 2013 : BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced.
Srirangalingam, U +5 more
core +1 more source
Benchmarking RNA Editing Detection Tools [PDF]
, 2023 RNA, like DNA and proteins, can undergo modifications. To date, over 170 RNA modifications have been identified, leading to the emergence of a new research area known as epitranscriptomics.
Sarah Rennie +6 more
core +1 more source