Results 51 to 60 of about 2,133,969 (419)
Identification of novel components of Trypanosoma brucei editosomes [PDF]
, 2003 The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Carmean, Nicole +6 more
core +2 more sources
Genomic Positional Dissection of RNA Editomes in Tumor and Normal Samples
Frontiers in Genetics, 2019 RNA editing is phenomenon that occurs in both protein coding and non-coding RNAs. Increasing evidence have shown that adenosine-to-inosine RNA editing can potentially rendering substantial functional effects throughout the genome.
Michael Chigaev +8 more
doaj +1 more source
Darned in 2013: inclusion of model organisms and linking with Wikipedia [PDF]
, 2012 DARNED (DAtabase of RNA EDiting, available at http://darned.ucc.ie) is a centralized repository of reference genome coordinates corresponding to RNA nucleotides having altered templated identities in the process of RNA editing.
Baranov, Pavel V. +3 more
core +4 more sources
An RNA editing fingerprint of cancer stem cell reprogramming [PDF]
, 2015 BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML).
Angela C Court +8 more
core +1 more source
REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
Nucleic Acids Res., 2020 RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary ...
L. Mansi +9 more
semanticscholar +1 more source
Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver [PDF]
, 2014 BackgroundRNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of
Billing, Anja M +11 more
core +3 more sources
Site-directed RNA editing: recent advances and open challenges
RNA Biology, 2021 RNA editing by cytosine and adenosine deaminases changes the identity of the edited bases. While cytosines are converted to uracils, adenines are converted to inosines.
Hamideh Khosravi, M. Jantsch
semanticscholar +1 more source
REDIdb: the RNA editing database [PDF]
Nucleic Acids Research, 2007 The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by ...
PICARDI E +3 more
openaire +4 more sources
Universal RNA editing in a human liver at the fetal stage [PDF]
, 2012 It is known that RNA editing occurs in human cells, which can change the information transmission from DNA to RNA and proteins. Most previous studies have focused on editing of the mRNAs. Here we reported that several kinds of RNAs, including miRNA, rRNA,
Chen, Huiping +4 more
core +1 more source
RNA Editing and Drug Discovery for Cancer Therapy
The Scientific World Journal, 2013 RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers.
Wei-Hsuan Huang +5 more
doaj +1 more source