Results 71 to 80 of about 2,109,918 (320)

RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification

Frontiers in Genetics, 2021
Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions.
Dean Light, Roni Haas, Mahmoud Yazbak, Tal Elfand, Tal Blau, Ayelet T. Lamm   +5 more
doaj   +1 more source

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations

Biomolecules, 2022
RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA–DNA differences, RDDs).
Korina Karagianni, Spyros Pettas, Georgia Christoforidou, Eirini Kanata, Nikolaos Bekas, Konstantinos Xanthopoulos, Dimitra Dafou, Theodoros Sklaviadis   +7 more
doaj   +1 more source

RNA editing signature during myeloid leukemia cell differentiation [PDF]

, 2017
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis, A Gallo, AS Shifera, BE Wulff, BJ Liddicoat, BL Bass, C Cenci, C Sundstrom, C Trapnell, C Trapnell, D Laxminarayana, E Picardi, E Picardi, G Camilli, H Aberle, H Li, JB Patterson, JC Hartner, JH Bahn, JM Desterro, Justin M. Thomas, K Nishikura, L Bazak, L Chen, M D'Antonio, M Daigneault, M Higuchi, M Vogler, MA Zipeto, MA Zipeto, N Mannion, N Paz-Yaacov, Q Jiang, Q Wang, Q Wang, R Marcucci, R XuFeng, RA Steinman, RJ Orlowski, S Tomaselli, S Tomaselli, T Hwang, TD Wu, TR Dawson, W Slotkin, Y Li, Y Pinto, YJ Crow, YS Baek   +48 more
core   +2 more sources

Is there any sense in antisense editing? [PDF]

Trends in Genetics 21, 544-7 (2005), 2005
A number of recent studies have hypothesized that sense-antisense RNA transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. Here we studied human and mouse genomic antisense regions, and found that the editing level in these areas is negligible.
arxiv   +1 more source

An RNA-Based Theory of Natural Universal Computation [PDF]

Journal of Theoretical Biology Volume 537, 21 March 2022, 110984, 2020
Life is confronted with computation problems in a variety of domains including animal behavior, single-cell behavior, and embryonic development. Yet we currently do not know of a naturally existing biological system that is capable of universal computation, i.e., Turing-equivalent in scope.
arxiv   +1 more source

Improving prime editing with an endogenous small RNA-binding protein

Nature
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1.
Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C Ward, Sébastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, L. Goudy, Ralf Schmidt, Sabrina C Solley, Luke A. Gilbert, Michelle M Chan, Daniel E. Bauer, Alex Marson, Lance R. Parsons, Britt Adamson   +18 more
semanticscholar   +1 more source

A cytosine deaminase for programmable single-base RNA editing

Science, 2019
Adding to the RNA editing toolbox A previously developed RNA editing system called REPAIR can base edit A to I in RNA by fusing the adenine deaminase domain of ADAR2 with catalytically dead CRISPR-Cas13.
Omar O. Abudayyeh, J. Gootenberg, B. Franklin, Jeremy Koob, M. Kellner, Alim Ladha, J. Joung, Paul Kirchgatterer, David B. T. Cox, Feng Zhang   +9 more
semanticscholar   +1 more source

RNA editing generates cellular subsets with diverse sequence within populations [PDF]

, 2016
RNA editing is a mutational mechanism that specifically alters the nucleotide content in transcribed RNA. However, editing rates vary widely, and could result from equivalent editing amongst individual cells, or represent an average of variable editing ...
Harjanto, D., Oates, Chris J., Papamarkou, Theodore, Papavasiliou, Anastasia, Papavasiliou, F. N., Rayon-Estrada, V.   +5 more
core   +1 more source

Atlas of RNA editing events affecting protein expression in aged and Alzheimers disease human brain tissue. [PDF]

, 2021
RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose sequence differs from the genome template. Brain RNA editing may be altered in Alzheimers disease (AD).
Allen, Mariet, Bennett, David, Dammer, Eric, De Jager, Philip, Duong, Duc, Ertekin-Taner, Nilüfer, Felsky, Daniel, Klein, Hans-Ulrich, Lah, James, Levey, Allan, Logsdon, Benjamin, Ma, Yiyi, McCabe, Cristin, Schneider, Julie, Seyfried, Nicholas, Wang, Minghui, Wang, Xue, White, Charles, Wingo, Thomas, Xu, Jishu, Zhang, Bin, Zhou, Maotian   +21 more
core   +1 more source