Results 71 to 80 of about 685,668 (343)

N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Nature Communications
The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter protein ...
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou   +9 more
doaj   +1 more source

Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer

Frontiers in Oncology, 2020
A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and ...
Chi Zhou, Zhiting Wei, Liye Zhang, Zhaoyi Yang, Qi Liu   +4 more
doaj   +1 more source

A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations

Biomolecules, 2022
RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA–DNA differences, RDDs).
Korina Karagianni, Spyros Pettas, Georgia Christoforidou, Eirini Kanata, Nikolaos Bekas, Konstantinos Xanthopoulos, Dimitra Dafou, Theodoros Sklaviadis   +7 more
doaj   +1 more source

A-to-I RNA editing does not change with age in the healthy male rat brain [PDF]

, 2013
RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events.
Andrew P. Holmes, Brian J. Merry, João Pedro de Magalhães, Shona H. Wood   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

RNA editing affects cis‐regulatory elements and predicts adverse cancer survival

Cancer Medicine, 2021
Background RNA editing exerts critical impacts on numerous biological processes and thus are implicated in crucial human phenotypes, including tumorigenesis and prognosis.
Yuan‐Ming Wu, Yan Guo, Hui Yu, Tao Guo
doaj   +1 more source

A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules [PDF]

, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Alfredo Ferro, Dario Veneziano, Giovanni Nigita   +2 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RNA editing enzymes: structure, biological functions and applications

Cell & Bioscience
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing.
Dejiu Zhang, Lei Zhu, Yanyan Gao, Yin Wang, Peifeng Li   +4 more
doaj   +1 more source

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source