Results 251 to 260 of about 247,454 (281)
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RNA FOLDING DURING TRANSCRIPTION
Annual Review of Biophysics and Biomolecular Structure, 2006The evolution of RNA sequence needs to satisfy three requirements: folding, structure, and function. Studies on folding during transcription are related directly to folding in the cell. Understanding RNA folding during transcription requires the elucidation of structure formation and structural changes of the RNA, and the consideration of intrinsic ...
Tao Pan
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Current Opinion in Structural Biology, 1995
The number of known motifs for RNA folding and RNA tertiary organization is expanding rapidly as we learn more about the diverse biological functions of RNA. Problems in protein and RNA folding have melded in recent investigations of ribonucleoprotein folding.
A M, Pyle, J B, Green
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The number of known motifs for RNA folding and RNA tertiary organization is expanding rapidly as we learn more about the diverse biological functions of RNA. Problems in protein and RNA folding have melded in recent investigations of ribonucleoprotein folding.
A M, Pyle, J B, Green
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Journal of Bioinformatics and Computational Biology, 2023
Most of the functional RNA elements located within large transcripts are local. Local folding therefore serves a practically useful approximation to global structure prediction. Due to the sensitivity of RNA secondary structure prediction to the exact definition of sequence ends, accuracy can be increased by averaging local structure predictions over ...
Waldl, Maria +6 more
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Most of the functional RNA elements located within large transcripts are local. Local folding therefore serves a practically useful approximation to global structure prediction. Due to the sensitivity of RNA secondary structure prediction to the exact definition of sequence ends, accuracy can be increased by averaging local structure predictions over ...
Waldl, Maria +6 more
openaire +2 more sources
Journal of Molecular Biology, 1999
We describe the RNA folding problem and contrast it with the much more difficult protein folding problem. RNA has four similar monomer units, whereas proteins have 20 very different residues. The folding of RNA is hierarchical in that secondary structure is much more stable than tertiary folding. In RNA the two levels of folding (secondary and tertiary)
I, Tinoco, C, Bustamante
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We describe the RNA folding problem and contrast it with the much more difficult protein folding problem. RNA has four similar monomer units, whereas proteins have 20 very different residues. The folding of RNA is hierarchical in that secondary structure is much more stable than tertiary folding. In RNA the two levels of folding (secondary and tertiary)
I, Tinoco, C, Bustamante
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Annual Review of Biophysics and Biomolecular Structure, 2005
▪ Abstract The problem of how ions influence the folding of RNA into specific tertiary structures is being addressed from both thermodynamic (by how much do different salts affect the free energy change of folding) and structural (how are ions arranged on or near an RNA and what kinds of environments do they occupy) points of view.
David E, Draper +2 more
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▪ Abstract The problem of how ions influence the folding of RNA into specific tertiary structures is being addressed from both thermodynamic (by how much do different salts affect the free energy change of folding) and structural (how are ions arranged on or near an RNA and what kinds of environments do they occupy) points of view.
David E, Draper +2 more
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Accounts of Chemical Research, 2005
Single-molecule experiments significantly expand our capability to characterize complex dynamics of biological processes. This relatively new approach has contributed significantly to our understanding of the RNA folding problem. Recent single-molecule experiments, together with structural and biochemical characterizations of RNA at the ensemble level,
Gregory, Bokinsky, Xiaowei, Zhuang
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Single-molecule experiments significantly expand our capability to characterize complex dynamics of biological processes. This relatively new approach has contributed significantly to our understanding of the RNA folding problem. Recent single-molecule experiments, together with structural and biochemical characterizations of RNA at the ensemble level,
Gregory, Bokinsky, Xiaowei, Zhuang
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Genetica, 1999
Catalysis in RNA is intimately connected to the folding. The small nucleolytic ribozymes function by a nucleophilic attack of the 2'-oxygen on the 3'-phosphate, in an SN2 mechanism. This requires an alignment of the 2'-O, 3'-P and 5'-O, that does not occur in normal A-form RNA. It is therefore likely that structural distortion plays a major role in the
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Catalysis in RNA is intimately connected to the folding. The small nucleolytic ribozymes function by a nucleophilic attack of the 2'-oxygen on the 3'-phosphate, in an SN2 mechanism. This requires an alignment of the 2'-O, 3'-P and 5'-O, that does not occur in normal A-form RNA. It is therefore likely that structural distortion plays a major role in the
openaire +2 more sources
Current Opinion in Structural Biology, 2004
Single-molecule studies of RNA folding and unfolding are providing impressive details of the intermediates that occur and their rates of interconversion. The folding and unfolding of RNA are controlled by varying the concentration of magnesium ions and measuring fluorescence energy transfer, or by applying force to the RNA and measuring the end-to-end ...
Bibiana, Onoa, Ignacio, Tinoco
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Single-molecule studies of RNA folding and unfolding are providing impressive details of the intermediates that occur and their rates of interconversion. The folding and unfolding of RNA are controlled by varying the concentration of magnesium ions and measuring fluorescence energy transfer, or by applying force to the RNA and measuring the end-to-end ...
Bibiana, Onoa, Ignacio, Tinoco
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RNA folding: models and perspectives
Current Opinion in Structural Biology, 2003Intrinsic events during RNA folding include conformational search and metal ion binding. Several experimentally testable models have been proposed to explain how large ribozymes accomplish folding. Future challenges include the validation of these models, and the correlation of experimental results and theoretical simulations.
Tobin R, Sosnick, Tao, Pan
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Nature Chemistry, 2020
RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.
Qi, Shen, Chenxiang, Lin
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RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.
Qi, Shen, Chenxiang, Lin
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