Results 261 to 270 of about 993,526 (301)
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Nature Chemistry, 2020
RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.
Qi, Shen, Chenxiang, Lin
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RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.
Qi, Shen, Chenxiang, Lin
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Current Opinion in Structural Biology, 1995
The number of known motifs for RNA folding and RNA tertiary organization is expanding rapidly as we learn more about the diverse biological functions of RNA. Problems in protein and RNA folding have melded in recent investigations of ribonucleoprotein folding.
A M, Pyle, J B, Green
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The number of known motifs for RNA folding and RNA tertiary organization is expanding rapidly as we learn more about the diverse biological functions of RNA. Problems in protein and RNA folding have melded in recent investigations of ribonucleoprotein folding.
A M, Pyle, J B, Green
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Annual Review of Biophysics and Biomolecular Structure, 2005
▪ Abstract The problem of how ions influence the folding of RNA into specific tertiary structures is being addressed from both thermodynamic (by how much do different salts affect the free energy change of folding) and structural (how are ions arranged on or near an RNA and what kinds of environments do they occupy) points of view.
David E, Draper +2 more
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▪ Abstract The problem of how ions influence the folding of RNA into specific tertiary structures is being addressed from both thermodynamic (by how much do different salts affect the free energy change of folding) and structural (how are ions arranged on or near an RNA and what kinds of environments do they occupy) points of view.
David E, Draper +2 more
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Current Opinion in Structural Biology, 2002
RNA folding in vivo is influenced by the cellular environment, the vectorial nature of transcription and translation, trans-acting factors and ion homeostasis. Specific RNA-binding proteins promote RNA folding by stabilizing the native structure or by guiding folding. In contrast, RNA chaperones, which are believed to interact nonspecifically with RNA,
Schroeder, Renée +3 more
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RNA folding in vivo is influenced by the cellular environment, the vectorial nature of transcription and translation, trans-acting factors and ion homeostasis. Specific RNA-binding proteins promote RNA folding by stabilizing the native structure or by guiding folding. In contrast, RNA chaperones, which are believed to interact nonspecifically with RNA,
Schroeder, Renée +3 more
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Journal of Molecular Biology, 1999
We describe the RNA folding problem and contrast it with the much more difficult protein folding problem. RNA has four similar monomer units, whereas proteins have 20 very different residues. The folding of RNA is hierarchical in that secondary structure is much more stable than tertiary folding. In RNA the two levels of folding (secondary and tertiary)
I, Tinoco, C, Bustamante
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We describe the RNA folding problem and contrast it with the much more difficult protein folding problem. RNA has four similar monomer units, whereas proteins have 20 very different residues. The folding of RNA is hierarchical in that secondary structure is much more stable than tertiary folding. In RNA the two levels of folding (secondary and tertiary)
I, Tinoco, C, Bustamante
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Journal of Bioinformatics and Computational Biology, 2023
Most of the functional RNA elements located within large transcripts are local. Local folding therefore serves a practically useful approximation to global structure prediction. Due to the sensitivity of RNA secondary structure prediction to the exact definition of sequence ends, accuracy can be increased by averaging local structure predictions over ...
Maria Waldl +6 more
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Most of the functional RNA elements located within large transcripts are local. Local folding therefore serves a practically useful approximation to global structure prediction. Due to the sensitivity of RNA secondary structure prediction to the exact definition of sequence ends, accuracy can be increased by averaging local structure predictions over ...
Maria Waldl +6 more
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Current Opinion in Structural Biology, 2004
Single-molecule studies of RNA folding and unfolding are providing impressive details of the intermediates that occur and their rates of interconversion. The folding and unfolding of RNA are controlled by varying the concentration of magnesium ions and measuring fluorescence energy transfer, or by applying force to the RNA and measuring the end-to-end ...
Bibiana, Onoa, Ignacio, Tinoco
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Single-molecule studies of RNA folding and unfolding are providing impressive details of the intermediates that occur and their rates of interconversion. The folding and unfolding of RNA are controlled by varying the concentration of magnesium ions and measuring fluorescence energy transfer, or by applying force to the RNA and measuring the end-to-end ...
Bibiana, Onoa, Ignacio, Tinoco
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A continuous analog for RNA folding
Bulletin of Mathematical Biology, 1989A linear segment in which a number of pairs of intervals of equal length are identified as potential stems is the subject of a folding problem analogous to inference of RNA secondary structure. A quantity of free energy (or equivalently, energy per unit length) is associated with each stem, and the various types of loops are assigned energy costs as a ...
Ferretti, Vincent, Sankoff, David
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Genetica, 1999
Catalysis in RNA is intimately connected to the folding. The small nucleolytic ribozymes function by a nucleophilic attack of the 2'-oxygen on the 3'-phosphate, in an SN2 mechanism. This requires an alignment of the 2'-O, 3'-P and 5'-O, that does not occur in normal A-form RNA. It is therefore likely that structural distortion plays a major role in the
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Catalysis in RNA is intimately connected to the folding. The small nucleolytic ribozymes function by a nucleophilic attack of the 2'-oxygen on the 3'-phosphate, in an SN2 mechanism. This requires an alignment of the 2'-O, 3'-P and 5'-O, that does not occur in normal A-form RNA. It is therefore likely that structural distortion plays a major role in the
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HIERARCHY AND DYNAMICS OF RNA FOLDING
Annual Review of Biophysics and Biomolecular Structure, 1997▪ Abstract The evidence showing that the self-assembly of complex RNAs occurs in discrete transitions, each relating to the folding of sub-systems of increasing size and complexity starting from a state with most of the secondary structure, is reviewed.
Brion, Philippe, Westhof, Eric
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